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| Changes and Significance of Serum Bilirubin and Uric Acid Levels in Patients with Type 2 Diabetic Nephropathy |
| HUANG Gui-rui, SUN Guo-ming |
| Department of Nephrology, Guangzhou University of Traditional Chinese Medicine, Guangzhou Guangdong,510000 |
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Abstract 【Objective】To investigate the changes and significance of serum bilirubin (TB) and uric acid (UA) levels in patients with type 2 diabetic nephropathy.【Methods】Among the type 2 diabetic patients diagnosed and treated in our hospital, 30 patients with normal urinary albumin excretion rate (UAER < 30mg/24h) were in the normal group, 30 patients with early type 2 diabetic nephropathy (DN) (30~300 mg/24h) were in the early group, and 30 patients with DN (>300 mg/24h) were in the DN group.The condition of diabetes mellitus, renal function index, serum TB and UA levels and their correlation with renal function index were compared among the three groups.【Results】HbA1c and fasting C-peptide in the DN group were significantly higher than those in the normal group and the early group (P<0.05); HbA1c and fasting C-peptide in the early group were significantly higher than those in the normal group (P<0.05); UAER and serum creatinine (SCr) in the DN group were significantly higher than those in the normal group and the early group (P<0.05); and endogenous creatinine clearance rate (CCr) in the early group was significantly higher than those in the normal group and the early group (P<0.05). UA in the DN group was significantly higher than that in the normal group (P<0.05), TB in the DN group was significantly lower than that in the normal group and the early group (P<0.05), UA in the early group was significantly higher than that in the normal group (P<0.05), TB in serum was negatively correlated with UAER, SCr and CCr (P<0.05), UA level was positively correlated with UAER, SCr and CCr (P<0.05). 【Conclusion】The occurrence and development of type 2 diabetic nephropathy is accompanied by the decrease of serum TB and the increase of UA level, which can be used as a new target for early diagnosis and clinical treatment of DN.
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Received: 20 April 2018
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[1] 侯清涛, 李芸, 李舍予,等.全球糖尿病疾病负担现状[J].中国糖尿病杂志, 2016, 24(1):92-96.
[2] 杨立勇.关注糖尿病微血管并发症研究进展[J].中国糖尿病杂志, 2016, 8(8):449-451.
[3] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(基层版)[J].中华全科医师杂志, 2013, 12(8):1227-1245.
[4] 中华医学会糖尿病学分会微血管并发症学组. 糖尿病肾病防治专家共识(2014年版)[J].中国糖尿病杂志, 2014, 6(11):792-801.
[5] 狄英波. 血清胆固醇、总胆红素、尿酸和尿微量蛋白在妊娠期糖尿病中的临床意义[J].中国妇幼保健, 2014, 29(8):1180-1181.
[6] Latif H, Iqbal A, Rathore R,et al. Correlation between Serum Uric Acid Level and Microalbuminuria in Type-2 Diabetic Nephropathy[J].Pakistan J Med Sci,2017, 33(6):1371-1375.
[7] Komers R, Xu B, Schneider J, et al. Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes[J].Br J Pharm,2016, 173(17):2573-2588.
[8] Hatanaka H, Hanyu H, Fukasawa R, et al. Peripheral oxidative stress markers in diabetes‐related dementia[J].Geriatr Gerontol Int,2016, 16(12):1312-1318.
[9] 季丰, 童天夫, 叶健. 2型糖尿病血清总胆红素、糖化血红蛋白水平及其与糖尿病肾病的相关性分析[J].广西医科大学学报, 2017, 34(9):1325-1328. |
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2019, Vol. 36 
