糖尿病肾病患者尿NGAL水平变化及其临床意义

doi:10.3969/j.issn.1671-7171.2019.03.031

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Abstract 【Objective】To investigate the changes and significance of serum neutrophil gelatinase-associated lipid carrier protein (NGAL) in patients with diabetic nephropathy (DN). 【Methods】 Fourty healthy volunteers were selected as group A, 40 patients with type 2 diabetes mellitus (group B), 40 patients with diabetes mellitus and microalbuminuria (group C, urinary albumin/creatinine 30-300 mg/g), 40 patients with diabetic albuminuria (group D, urinary albumin/creatinine greater than 300 mg/g). NGAL, serum creatinine (SCr), urea nitrogen (BUN) and urinary microalbumin (UmALB) levels were measured and compared among the four groups.【Results】The levels of NGAL and UmALB in the group C and D were significantly higher than those in the group A and the group B (P<0.05), and the levels of NGAL, SCr, BUN and UmALB in the group D were significantly higher than those in the group A, group B and group C (P<0.05). NGAL was positively correlated with SCr, BUN and UmALB in DN patients (P<0.05). The critical value of NGAL in diagnosing DN was 80.04 ng/mL, the sensitivity was 85.29%, the specificity was 76.04%, the missed diagnosis rate was 14.71%, the misdiagnosis rate was 23.96%, and the AUC value under ROC curve was 0.807.【Conclusion】The level of NGAL increased in the early stage of DN patients, and it has a certain correlation with the degree of renal function damage. Early detection of NGAL has a certain value in the differential diagnosis of DN.

Received: 22 January 2019

PACS:

R587.24

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	ZHANG Jian-lin
	LIN Jian-min

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ZHANG Jian-lin,LIN Jian-min. Changes of Urinary NGAL Levels in Patients with Diabetic Nephropathy and its Clinical Significance[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 507-509.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.03.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I3/507

[1] Jia G, Di F, Wang Q,et al. Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus[J].PLoS One,2015,10(11):808-810.
[2] 陈薇,鲍官虎. NGAL测定在糖尿病肾脏疾病中的价值及其与炎症因子的相关性[J].安徽医科大学学报,2018,53(8):1276-1280.
[3] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,24(10):893-942.
[4] Su S, Wang W, Sun T, et al. Smoking as a risk factor for diabetic nephropathy: a meta-analysis[J].Int Urol Nephrol,2017,49(10):1801-1807.
[5] Rodriguez Cubillo B, Rodriguez B, Calvo M, et al. Risk factors of recurrence of diabetic nephropathy in renal transplants[J].Transplant Proc,2016,48(9):2956-2958.
[6] Song K, Jeong J, Kim M K,et al. Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type?2 diabetes mellitus[J].J Diabetes Investig,2018,34(6):90-93.
[7] 陆松松,康蕊,李学茹,等. 尿泛素-核糖体结合蛋白52、尿微量清蛋白、尿视黄醇结合蛋白联检在早期糖尿病肾损伤诊断中的价值[J].中国老年学杂志,2018,38(7):1576-1578.
[8] 杨春杰,胡晓娇,崔琦. 随机测定尿微量白蛋白与尿肌酐比值对妊娠期糖尿病患者早期肾损伤的诊断价值[J].中国妇幼保健,2017,32(11):2320-2323.
[9] 樊玲英,俸家富. 血清C1q和NGAL及CysC联合检测对早期糖尿病肾病辅助诊断的临床评价[J].中华检验医学杂志,2018,41(11):847-852.
[10] 杨朝菊,耿瑞丽,申艳梅,等. 糖尿病肾病患者血清中性粒细胞明胶酶相关载脂蛋白与铁蛋白及转铁蛋白饱和度的相关性分析[J].山东医药,2016,56(47):67-68.
[11] 周青霞. 血清糖化血红蛋白、C反应蛋白及微量白蛋白水平与老年糖尿病肾病患者肾微血管病变的相关性[J].中国老年学杂志,2015,35(4):900-902.
[12] 杨朝菊,赵培,张明明,等. 早期糖尿病肾病血清NGAL与致动脉硬化指数的关系[J].中国动脉硬化杂志,2017,25(11):1149-1151.
[13] 张玲,陆晨,杨淑芬,等. 尿中性粒细胞明胶酶相关脂质运载蛋白预测老年2型糖尿病患者颈动脉硬化的价值[J].中华老年心脑血管病杂志,2018,20(4):396-400.
[14] 张会芬,杨宏秀,刘丽,等. 血清中性粒细胞明胶酶相关脂质运载蛋白、胱抑素C及尿白蛋白肌酐比值、N-乙酰-β-D-氨基葡萄糖苷酶检测在早期糖尿病肾脏疾病中的应用价值[J].中国糖尿病杂志,2018,26(4):309-315.