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| Clinical Observation of Azithromycin Combined with Montelukast in the Treatment of Cough Variant Asthma with Mycoplasma Pneumoniae Infection in Children |
| ZHANG Xiao-hong, LI Ling-mei |
| Department of Pediatrics; Panzhihua General Hospital of Panzhihua Iron and Steel Group Panzhihua, Sichuan, 617023 |
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Abstract 【Objective】To investigate the efficacy of azithromycin combined with montelukast in the treatment of children of cough variant asthma (CVA) with Mycoplasma pneumonia (MP) infection . 【Methods】A total of 120 cases of children diagnosed with CVA and MP infection were selected for the study and divided into two groups with 60 cases in each group according to the random table method. The control group (B group) was treated with azithromycin, while the observation group (A group) was additionally given montelukast on the basis of azithromycin treatment. The treatments in both groups lasted 7 days. After the course of treatment, the clinical efficacies of the two groups were observed and the serum levels of inflammatory factors and immunoglobulins were compared between the two groups before and after treatment. Adverse reactions were recorded as well. 【Results】The total effective rate was 83.3% in B group, which was significantly lower than that in A group with 95.0% (P<0.05). The levels of ECP, IL-5, MMP-9,TIMP-1 and IgE , and EOS in the two groups were significantly lower than those before treatment (P<0.05) and the indexes in A group after treatment were significantly lower than those in B group (P<0.05). The cough disappearance time, wheezing disappearance time, temperature recovery time in B group were significantly better than those in A group. The overall incidence rate of adverse reactions was 11.67%(7/60)in B group, which was not significantly different from that in A group with 8.33%( 5/60) (P>0.05). 【Conclusion】Azithromycin combined with montelukast can have a significant clinical efficacy, can reduce airway hypersensitivity and airway inflammation, and promote rehabilitation of children in the treatment of CVA with MP infection.
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Received: 23 December 2016
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2018, Vol. 35 
