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| Effect of Oxycodone Hydrochloride Injection as Preemptive Analgesia on Analgesic Action and Pain-producing Factors in Segmental Mastectomy |
| WANG Chen-zhi, GAN Jian-hui, HE Shuang-liang, et al |
| The Affiliated Tangshan people Hospital of North China University of Science and Technology, Tangshan, 063000, China |
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Abstract 【Objective】To explore the effect of oxycodone hydrochloride injection as preemptive analgesia on the analgesic effect and plasma pain-producing factors in segmental resection of breast cancer mastectomy. 【Methods】 A total of 60 patients who underwent segmental mastectomy in our hospital under local anesthesia were randomly divided into two groups: group A and group B. Patients in group A received intravenous oxycodone hydrochloride injection 10mg dissolved in 10ml of normal saline before local anesthesia, while patients in group B were injected with 10ml of normal saline. The vital signs of MAP, HR, SpO2 and VAS scores at the time of surgical incision (T1), 10 min after incision (T2), at the termination of operation (T3), and 3h after the operation (T4) were recorded. Peripheral venous blood(3ml) was drawn to detect 5-HT and substance P at T1~T4. The total dose of local anesthetic and adverse reactions during surgery were compared as well.【Results】 Compared to group B, MAP in group A was lower at T1 and T2, while HR was lower at T1, T2 and T3 (P<0.05). Patients in group A had significantly lower VAS scores at T1~ T4 than those in group B(P<0.05). Compared to T1, the plasma levels of substance P and 5-HT in group B were elevated to some degree at T2~ T4, which were also higher than those in group A (P<0.05). While there were no significant differences of substance P and 5-HT plasma levels in group A at T1~T4(P>0.05). Compared to group B, substance P and 5-HT levels in group A were lower than those in group B at T2~T4 (P<0.05). Meanwhile, the total dose of local anesthetic in patients of group A was significantly lower than that in group B( P<0.05). However, there was no statistically significant difference in the incidence of adverse reactions such as nausea and vomiting between the two groups (P>0.05). 【Conclusion】Application of preemptive analgesia with oxycodone hydrochloride injection in breast cancer patients having segmental mastectomy can significantly alleviate intraoperative and postoperative pain intensity, decrease levels of plasma 5-HT and substance P, and reduce the amount of local anesthetic used.
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Received: 29 June 2018
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2018, Vol. 35 
