Abstract 【Objective】To explore the result of quantitative computed tomography (CT) and its clinical significance on patients with pulmonary alveolar proteinosis (PAP) after bronohoalveolar lavage. 【Methods】The clinical data of 30 patients with PAP were selected. All patients were treated with BAL.The pulmonary function indexes of patients were measured by pulmonary function test before and after treatment [forced vital capacity (FVC), carbon monoxide diffusion volume (DLCO), forced expiratory volume (FEV1) in 1 second, maximum ventilation value (MVV) / percentage of predicted value. That is, FVC%, DLCO%, FEV1%,MVV%].Pulmonary ventilation function indexes [arterial oxygen / carbon dioxide partial pressure (PaO2 and PaCO2), blood oxygen saturation (SaO2)] were compared before and after treatment. The mean density of lung, the total volume of lung gas, the total mass of lung, the mean value of CT and so on were measured by quantitative CT. MMRC score was used to evaluate the degree of dyspnea. 6 min walking test was used to evaluate dyspnea symptoms and exercise endurance.【Results】The difference of FVC%, FEV1%, PaCO2 before and after BAL was statistically significant (P>0.05). The DLCO%, MVV%, PaO2, SaO2 value after BAL was significantly higher than that before BAL (P<0.05). The mean lung CT value, total lung weight and lung density were significantly lower than those before BAL (P<0.05). The total volume of lung gas was significantly higher than that before BAL (P<0.05). The MMRC score of patients after BAL was significantly lower than that before BAL, and the 6 min -walking distance was significantly higher than that of BAL (P<0.05). 【Conclusion】The clinical effect of BAL in the treatment of PAP is better. Quantitative CT can be used to evaluate the effect of bronohoalveolar lavage.
WANG Fen. Evaluation of the Effect of Quantitative CT on Bronchoalveolar Lavage in Patients with Pulmonary Alveolar Proteinosis[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(10): 1914-1916.
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