性激素水平、子宫超声参数及骨龄指数联合检测对女童快进展型中枢性性早熟的预测价值

doi:10.3969/j.issn.1671-7171.2025.12.013

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摘要 【目的】探讨性激素水平、子宫超声参数及骨龄指数联合检测对女童快进展型中枢性性早熟(rapid progressive central precocious puberty,RP-CPP)的预测价值。 【方法】选取2023年1月至12月在本院初诊为中枢性性早熟(central precocious puberty,CPP)的168例女童为研究对象,根据青春期进展速度分为RP-CPP组(n=88)和慢进展型中枢性性早熟(slowly progressive CPP,SP-CPP)组(n=80)。比较两组临床资料,采用多因素Logistic回归分析CPP女童进展为RP-CPP的影响因素,采用受试者工作特征(ROC)曲线分析子宫体积、骨龄指数对CPP女童进展为RP-CPP的预测价值。【结果】RP-CPP组和SP-CPP组女童初诊时的身高、体重、体重指数(BMI)、黄体生成素、卵泡刺激素、骨龄指数、子宫体积、卵巢平均体积比较,差异有统计学意义(P<0.05)。Logistic回归分析显示:骨龄指数及子宫体积是CPP女童进展为RP-CPP的影响因素(P<0.05)。ROC曲线分析显示:骨龄指数为1.20时,其预测CPP女童进展为RP-CPP的曲线下面积(AUC)为0.686;子宫体积为1.664 mL时,其预测CPP女童进展为RP-CPP的AUC为0.805。【结论】骨龄指数、子宫体积对CPP女童进展为RP-CPP具有一定的预测价值,当骨龄指数为1.20、子宫体积为1.664 mL时,提示CPP女童进展为RP-CPP的可能性较大,其可以作为诊断RP-CPP的辅助指标。

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	文欢
	刘凌萍
	刘金桥

关键词 ：青春期,早熟, 性腺甾类激素, 超声检查, 骨骼年龄测定, 儿童

Abstract：【Objective】 To explore the predictive value of combined detection of sex hormone levels, uterine ultrasound parameters and bone age index in girls with rapidly progressive central precocious puberty (RP-CPP). 【Methods】 A total of 168 girls initially diagnosed with central precocious puberty (CPP) in our hospital from January to December 2023 were selected as the research subjects. According to the progression rate of puberty, they were divided into the RP-CPP group (n=88) and the slowly progressive central precocious puberty (SP-CPP) group (n=80). The clinical data of the two groups were compared. Multivariate Logistic regression analysis was used to identify the influencing factors for the progression of CPP to RP-CPP in girls. Receiver operating characteristic (ROC) curve was adopted to analyze the predictive value of uterine volume and bone age index for the progression of CPP to RP-CPP in girls. 【Results】 There were significant differences in height, weight, body mass index (BMI), luteinizing hormone, follicle-stimulating hormone, bone age index, uterine volume and mean ovarian volume between the RP-CPP group and the SP-CPP group at the initial diagnosis (P<0.05). Logistic regression analysis showed that bone age index and uterine volume were the influencing factors for the progression of CPP to RP-CPP in girls. ROC curve analysis indicated that when the bone age index was 1.20, the area under the curve (AUC) of bone age index for predicting the progression of CPP to RP-CPP in girls was 0.686; when the uterine volume was 1.664 mL, the AUC of uterine volume for predicting the progression of CPP to RP-CPP in girls was 0.805. 【Conclusion】 Bone age index and uterine volume have certain predictive value for the progression of CPP to RP-CPP in girls. When the bone age index is 1.20 and the uterine volume is 1.664 mL, it suggests a high possibility of CPP progressing to RP-CPP in girls, and these indicators can be used as auxiliary indexes for the diagnosis of RP-CPP.

Key words： Puberty, Precocious Gonadal Steroid Hormones Ultrasonography Age Determination by Skeleton Child

收稿日期: 2025-03-05

中图分类号:

R725.85

通讯作者: *E-mail:826423695@qq.com

引用本文:

文欢, 刘凌萍, 刘金桥. 性激素水平、子宫超声参数及骨龄指数联合检测对女童快进展型中枢性性早熟的预测价值[J]. 医学临床研究, 2025, 42(12): 2061-2063.
WEN Huan, LIU Lingping, LIU Jinqiao. Predictive Value of Combined Detection of Sex Hormone levels, Uterine Ultrasound Parameters and Bone Age Index in Girls with Rapidly Progressive Central Precocious Puberty. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2061-2063.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.12.013 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I12/2061

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