Abstract：【Objective】To explore the efficacy of magnetic resonance perfusion weighted imaging(PWI) combined with diffusion weighted imaging(DWI) in distinguishing the grading of gliomas. 【Methods】 A retrospective analysis was conducted on 70 patients with surgically and pathologically confirmed gliomas admitted to two hospitals from October 2021 to October 2022(40 cases of low-grade gliomas and 30 cases of high-grade gliomas). The regional cerebral blood flow(rCBF) and apparent diffusion coefficient(ADC) of the tumor parenchyma area, peritumoral edema area, and corresponding normal brain parenchyma on the opposite side were compared, and the relative rCBF(rrCBF) and relative ADC(rADC) of the tumor parenchyma area and peritumoral edema area of patients with different grades of gliomas were compared. The Receiver Operating Characteristic(ROC) curve was drawn to evaluate the efficacy of rrCBF and rADC alone and in combination in distinguishing the grading of gliomas.【Results】The rCBF in the tumor parenchyma area was higher than that in the peritumoral edema area and normal brain parenchyma(P<0.05), while the ADC was lower than that in the peritumoral edema area and normal brain parenchyma(P<0.05); The rCBF in the peritumoral edema area was higher than that in the normal brain parenchyma(P<0.05), and the ADC was lower than that in the normal brain parenchyma(P<0.05). The rrCBF in the tumor parenchyma of low-grade glioma patients was lower than that of high-grade glioma patients(P<0.05), and the rADC was higher than that of high-grade glioma patients(P<0.05). The rrCBF in the peritumoral edema area of low-grade glioma patients was lower than that of high-grade glioma patients(P<0.05), and there was no statistically significant difference in rADC compared to high-grade glioma patients(P>0.05). The ROC curve analysis results showed that both rrCBF and rADC had certain discriminative effects on the grading of gliomas, with areas under the curves of 0.898 and 0.870, sensitivity of 0.867 and 0.900, and specificity of 0.800 and 0.775, respectively; The area under the curve for distinguishing the grading of gliomas using two methods was 0.954, with a sensitivity of 0.933 and a specificity of 0.975. 【Conclusion】PWI and DWI have certain differential efficacy in the grading of gliomas, and their combined differential efficacy is higher, which is worth actively promoting in clinical practice.
郭松, 宋朝晖, 张首宁. 磁共振灌注加权成像联合扩散加权成像鉴别脑胶质瘤分级的效能分析[J]. 医学临床研究, 2024, 41(6): 871-874.
GUO Song, SONG Chaohui, ZHANG Shouning. Efficiency Analysis of Magnetic Resonance Perfusion Weighted Imaging combined with Diffusion Weighted Imaging in Distinguishing the Grading of Gliomas. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 871-874.
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2024, Vol. 41 
