强脉冲光联合超分子水杨酸对光老化患者皮肤特征评分及皮肤屏障功能的影响

doi:10.3969/j.issn.1671-7171.2024.06.014

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摘要【目的】探讨强脉冲光(delicate pulse light,DPL)联合超分子水杨酸治疗对光老化患者皮肤特征评分和皮肤屏障功能的影响。【方法】选取2021年4月至2023年4月永城市人民医院收治的96例光老化患者,按照随机数字表法将患者分为观察组和对照组,每组48例。对照组患者接受DPL治疗,观察组患者接受DPL联合超分子水杨酸治疗。比较两组治疗前后皮肤质地[VISIA皮肤图像评分(VISIA complexion analysis system,VISIA)]、屏障功能[pH、皮肤含水量、经皮水分丢失(transepidermal water loss,TEwL)、皮肤油脂含量]、皮肤改善程度[整体美学改善评分(global aesthetic improvement scale,GAIS)、光老化整体评分(global sun damage score, GSDS)],记录两组不良反应(如红斑、水肿、瘢痕产生、色素沉着)发生情况并比较。【结果】观察组治疗后皮肤纹理、皱纹、毛孔、色斑和紫质评分均显著低于对照组;观察组治疗后皮肤pH值和TEwL显著低于对照组,皮肤含水量和油脂含量高于对照组;治疗后,观察组GSDS显著低于对照组(P<0.05), GAIS显著高于对照组(P<0.05)。观察组患者不良反应总发生率显著低于对照组,差异有统计学意义(P<0.05)。【结论】DPL联合超分子水杨酸治疗对于改善光老化患者的皮肤特征和增强皮肤屏障功能具有显著效果,并可显著降低不良反应发生率,值得临床推广应用。

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	张龑
	石庆
	翟子绮

关键词 ：皮肤衰老, 强脉冲光疗法/方法, 水杨酸, 皮肤

Abstract：【Objective】To explore the effects of combined treatment with delicate pulsed light(DPL) and supramolecular salicylic acid on skin characteristics and skin barrier function in photoaging patients. 【Methods】A total of 96 patients with photoaging admitted to Yongcheng People's Hospital from April 2021 to April 2023 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 48 patients in each group. The control group received DPL treatment; The observation group patients received DPL combined with supramolecular salicylic acid treatment. We compared the skin texture [VISIA complex analysis system(VISIA)], barrier function [pH, skin moisture content, transdermal water loss(TEwL), skin oil content], skin improvement degree [global aesthetic improvement scale(GAIS), and global sun damage score(GSDS)] before and after treatment between two groups, and recorded the occurrence of adverse reactions(such as erythema, edema, scar formation, and pigmentation) in both groups.【Results】After treatment, the observation group had significantly lower skin texture, wrinkles, pores, pigmentation, and purple score than the control group; After treatment, the skin pH and TEwL in the observation group were significantly lower than those in the control group, while the skin moisture and oil content were higher than those in the control group; After treatment, the GSDS of the observation group was significantly lower than that of the control group(P<0.05), and the GAIS was significantly higher than that of the control group(P<0.05). The total incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). 【Conclusion】The combination of DPL and supramolecular salicylic acid treatment has a significant effect on improving skin characteristics and enhancing skin barrier function in photoaging patients, and can significantly reduce the incidence of adverse reactions. It is worthy of clinical promotion and application.

Key words： Skin Aging Intense Pulsed Light Therapy/MT Salicylic Acid Skin

收稿日期: 2024-01-30

中图分类号:

R622.1

引用本文:

张龑, 石庆, 翟子绮. 强脉冲光联合超分子水杨酸对光老化患者皮肤特征评分及皮肤屏障功能的影响[J]. 医学临床研究, 2024, 41(6): 849-852.
ZHANG Yan, SHI Qing, ZHAI Ziqi. The Effect of Delicate Pulsed Light Combined with Supramolecular Salicylic Acid on Skin Characteristic Score and Skin Barrier Function in Photoaging Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 849-852.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.06.014 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I6/849

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