Abstract：【Objective】To investigate the effects of sevoflurane combined anesthesia on hemodynamics and pain factors in patients undergoing gynecological laparoscopic surgery.【Methods】There were 86 patients with gynecological diseases treated by laparoscopic surgery in our hospital and random divided into the observation group and the control group (n=43).The control group received propofol combined anesthesia, and the observation group received sevoflurane combined anesthesia. The anesthesia effects, heart rate (HR), mean arterial pressure (MAP) and other hemodynamic indicators before induction (T0), intubation (T1), intubation 5 min (T2), skin incision (T3), post-pneumoperitoneum (T4), and extubation (T5) were compared between the two groups. Serum levels of pain factors such as 5-HT, PGE2, β-endorphin (β-EP) and substance P (SP) at 6 h, 12 h and 24 h postoperatively, and the occurrence of postoperative adverse reactions of the two groups was compared as well.【Results】There was no difference in anesthesia time between the two groups (P>0.05).The recovery time of spontaneous breathing, eye opening time, language response time, recovery time of orientation and extubation time in observation group were shorter than those in control group (P<0.05). At T3, HR of observation group was higher than that of control group at the same point (P<0.05). At T2, T3 and T4, the MAP of observation group was higher than that of control group (P<0.05). There were no differences in HR and MAP between the two groups at other time points (P>0.05). There were no differences in the incidence of 5-HT, PGE2, β-EP, SP and adverse reactions between two groups before and after operation (P>0.05).【Conclusion】sevoflurane combined anesthesia can maintain hemodynamic stability, promote postoperative resuscitation and effectively regulate pain factors in patients undergoing gynecological laparoscopic surgery, and the incidence of adverse reactions is low.
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2024, Vol. 41 
