Abstract：【Objective】To explore the relationship among serum 25-hydroxyvitamin D [25-(OH)D] level, low-density lipoprotein cholesterol (LDL-C) level, and the classification of hypertension in hypertensive patients.【Methods】According to the hypertension grading standards, 371 hypertensive patients treated in our hospital were divided into grade 1 hypertension (120 cases), grade 2 hypertension (124 cases) and grade 3 hypertension (127 cases). While 391 healthy individuals undergoing physical examinations at our hospital during the same period were selected as the control group. General information of all participants was collected. Fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), creatinine (Cr), high-density lipoprotein cholesterol (HDL-C), 25-(OH)D, and LDL-C levels were measured. Correlation analysis was conducted between 25-(OH)D and LDL-C levels. Multifactorial logistic regression analysis was used to analyze the risk factors influencing the occurrence of hypertension.【Results】Compared to the control group, the hypertensive group showed significantly higher levels of body mass index (BMI), smoking proportion, systolic blood pressure (SBP), diastolic blood pressure (DBP), FBG, and LDL-C (P<0.05); while the level of 25-(OH)D in the hypertensive group was significantly lower than that in the control group (P<0.05). The BMI, FBG, and LDL-C of hypertensive patients increased with the grade of hypertension (P<0.05), meanwhile the level of 25-(OH)D decreased with the grade of hypertension (P<0.05). The correlation analysis showed that patients' BMI, smoking, SBP, DBP, and FBG were positively correlated with serum LDL-C level (P<0.05) and negatively correlated with 25-(OH)D level (P<0.05). Multifactorial logistic regression analysis showed that FBG and LDL-C were independent risk factors for hypertension (P<0.05), while HDL-C and 25-(OH)D were protective factors against hypertension (P<0.05).【Conclusion】Low level of 25-(OH)D and high level of LDL-C in hypertensive patients are closely related to the blood pressure classification (grades) of hypertension.
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2024, Vol. 41 
