Abstract：【Objective】To explore the analgesic effect and safety of Sufentanil combined with Parecoxib Sodium in secondary cesarean section. 【Methods】A total of 94 parturients scheduled for secondary cesarean section were randomly divided into an observation group and a control group, with 47 cases in each. The control group received Sufentanil for analgesia, while the observation group was given a combination of Sufentanil and Parecoxib Sodium for pain relief. Perioperative parameters of both groups were compared, including operation time, blood loss, fluid replenishment, and oxytocic types. The Visual Analog Scale (VAS) was used to assess and compare the pain level of the parturients in both groups at 3 min (T1), 5 min (T2), 10 min (T3), 20 min (T4), 30 min (T5) post-analgesia, and at the end of surgery (T6). Hemodynamic parameters [oxygen saturation (SPO2), heart rate (HR), respiratory rate (RR)] were monitored and compared at 1 h, 6 h, 24 h, and 48 h postoperatively. Adverse reactions during the medication period were calculated. 【Results】There were no significant differences in operation time, blood loss, fluid replenishment, and oxytocic types between the observation and the control groups (P>0.05). At T1, T2, T3, T4, T5, T6, the VAS scores of the observation group were significantly lower than those of the control group (P<0.05). At 1 h, 6 h, 24 h, and 48 h postoperatively, there were no significant differences in SPO2, HR, and RR levels between the observation and control groups (P>0.05). The incidence of adverse reactions was not significantly different between the two groups (P>0.05). 【Conclusion】The analgesic effect of Sufentanil combined with Parecoxib Sodium in secondary cesarean section is superior to that of Sufentanil alone. It can maintain stable hemodynamics and has a high safety profile, making it clinically valuable.
[1] DU M Q, QIU Q, HAO D M, et al . Recognition of uterine contractions with electrohysterogram and exploring the best electrode combination[J].Technol Health Care,2022,30(1):235-242.
[2] GAMEZ B H, HABIB A S . Predicting severity of acute pain after cesarean delivery: a narrative review[J].Anesthesia Analgesia,2018,126(5):1606-1614.
[3] 阮剑辉,宋晓阳,杨丽,等.预充量对脉冲式镇痛在二次剖宫产术后疼痛敏感性的影响[J].广东医学,2019,40(14):2004.
[4] KOWALSKI G, ZAWADZKI M, LEPPERT W, et al .Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds[J].Burns,2021,47(4):880-887.
[5] CHEN F F, FAN Y F, ZHU S S . Postoperative analgesic effect of parecoxib sodium local anesthesia in patients with breast cancer through systematic review and meta-analysis[J].Gland Surg,2021,10(11):3082-3096.
[6] USHIJIMA S, UKIMURA O, OKIHARA K, et al . Visual analog scale questionnaire to assess quality of life specific to each symptom of the International Prostate Symptom Score[J].J Urol,2006,176(2):665-671.
[7] 高兰翠,孙士莹,陶彩霞,等.二次剖宫产术中切除原子宫切口瘢痕组织对子宫瘢痕憩室形成的预防作用观察[J].中国妇产科临床杂志,2021,22(5):530-531.
[8] 钱夏丽,朱伟,韩传宝.羟考酮复合布托啡诺用于二次剖宫产术后静脉自控镇痛的效果[J].临床麻醉学杂志,2019,35(5):444-447.
[9] 范晴晴,回翔,谢菡,等.ABCB1C3435T基因多态性对阿片类药物术后镇痛效果的影响[J].中国医院药学杂志,2019,39(13):1379-1385.
[10] 邓红波,封享兰,张宗泽,等.舒芬太尼或羟考酮自控静脉镇痛联合腰方肌阻滞用于剖宫产术后镇痛的效果[J].临床麻醉学杂志,2020,36(2):124-127.
[11] 黄唯,李彬,何虹.纳布啡联合舒芬太尼在剖宫产术后镇痛中的效果及对应激反应、安全性的影响[J].检验医学与临床,2021,18(23):3366-3368.
[12] BIAN Y Y, WANG L C, QIAN W W, et al . Role of parecoxib sodium in the multimodal analgesia after total knee arthroplasty:a randomized double-blinded controlled trial[J].Orthop Surg,2018,10(4):321-327.
[13] 江婷婷,朱云联,陈慧群,等.酮咯酸氨丁三醇与帕瑞昔布钠对地佐辛在剖宫产术后镇痛效应影响的比较[J].广东医学,2018,39(1):220-222.
[14] 徐丽,王一男,李晓光.帕瑞昔布钠联合舒芬太尼多模式镇痛对宫颈癌根治术术后疼痛及应激反应的影响[J].中国计划生育学杂志,2019,27(5):580-584.
2024, Vol. 41 
