The Effect of Atomoxetine Hydrochloride Combined with Auditory Integration Training in the Treatment of Attention Deficit Hyperactivity Disorder in Children
MOU Chunyan, HAN Bo
Baoji Maternal and Child Health Hospital,Baoji Shaanxi 721000
Abstract：【Objective】To explore the efficacy of atomoxetine hydrochloride combined with auditory integration training(AIT) in the treatment of attention deficit hyperactivity disorder(ADHD) in children.【Methods】 A total of 210 children with ADHD admitted to our hospital from April 2021 to August 2022 were selected and randomly divided into a control group and an observation group according to a random number table method,with 105 cases in each group.The control group was treated with atomoxetine hydrochloride,while the observation group was treated with atomoxetine hydrochloride combined with AIT. The response time,error number,and missed report number of the two groups were compared,as well as the scores of the Chinese version of ADHD rating scale-parent version(ADHDRS-Ⅳ-P),combined raven's test(CRT),clinical efficacy,and adverse reactions. 【Results】After treatment,the response time,error number,and missed report number of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05). The attention deficit,hyperactivity/impulsivity,oppositional defiance,and total scores of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05). The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05). After treatment,the scores of reasoning ability,similarity comparison ability,perceptual discrimination ability,serial relationship ability,abstract reasoning ability,and IQ number of the two groups were higher than those before treatment(P<0.05),and the observation group was higher than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 Atomoxetine hydrochloride combined with AIT has better clinical efficacy in the treatment of ADHD in children,as well as enhance their cognitive ability,and is safe and reliable.
牟春燕, 韩波. 盐酸托莫西汀联合听觉统合训练治疗儿童注意缺陷多动障碍的效果[J]. 医学临床研究, 2023, 40(11): 1645-1648.
MOU Chunyan, HAN Bo. The Effect of Atomoxetine Hydrochloride Combined with Auditory Integration Training in the Treatment of Attention Deficit Hyperactivity Disorder in Children. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1645-1648.
[1] RUBIA K,WESTWOOD S,AGGENSTEINER P M,et al. Neurotherapeutics for attention deficit/hyperactivity disorder(ADHD):a review[J].Cells,2021,10(8):2156-2164. [2] KAZDA L,BELL K,THOMAS R,et al. Overdiagnosis of attention-deficit/hyperactivity disorder in children and adolescents:a systematic scoping review [J].JAMA Netw Open,2021,4(4):335-342. [3] BLADER J C. Attention-deficit hyperactivity disorder and the dysregulation of emotion generation and emotional expression [J].Child Adolesc Psychiatr Clin N Am,2021,30(2):349-360. [4] HINSHAW S P,NGUYEN P T,O'GRADY S M,et al. Annual research review:attention-deficit/hyperactivity disorder in girls and women:underrepresentation,longitudinal processes,and key directions [J].J Child Psychol Psychiatry,2022,63(4):484-496. [5] 中华医学会儿科学分会发育行为学组.注意缺陷多动障碍早期识别、规范诊断和治疗的儿科专家共识[J].中华儿科杂志,2020,58(3):188-193. [6] 周静,李红叶,孔永红.哌甲酯治疗汉族儿童注意缺陷多动障碍疗效与GRIN2B基因多态性的关系[J].儿科药学杂志,2020,26(5):35-38. [7] 王栋,狄敏,钱明. 联合型瑞文测验中国儿童常模第三次修订[J].中国临床心理学杂志,2007,15(6):559-561. [8] BRIKELL I,BURTON C,MOTA N R,et al. Insights into attention-deficit/hyperactivity disorder from recent genetic studies [J].Psychol Med,2021,51(13):2274-2286. [9] TAKAHASHI N,ISHIZUKA K,INADA T. Peripheral biomarkers of attention-deficit hyperactivity disorder:Current status and future perspective [J].J Psychiatr Res,2021,137(2):465-470. [10] MATTINGLY G W,WILSON J,UGARTE L,et al. Individualization of attention-deficit/hyperactivity disorder treatment:pharmacotherapy considerations by age and co-occurring conditions [J].CNS Spectr,2021,26(3):202-221. [11] GU Y,ZHU Y,BROWN K W. Mindfulness and Attention Deficit Hyperactivity Disorder:A Neuropsychological Perspective [J].J Nerv Ment Dis,2021,209(11):796-801. [12] LIN H Y,CHANG W D,HSIEH H C,et al. Relationship between intraindividual auditory and visual attention in children with ADHD [J].Res Dev Disabil,2021,108(3):103-114. [13] BENCH J,JACOBS K,FURLONGER B. On differentiating auditory processing disorder(APD) from attention deficit disorder(ADD):an illustrative example using the Cattell-Horn-Carroll(CHC) model of cognitive abilities[J].Int J Audiol,2020,59(3):224-229. [14] 陈一心,周洋,高润,等.经AIT改善听觉传导功能的孤独症谱系障碍患儿核心症状的变化分析[J].中华行为医学与脑科学杂志,2020,29(2):142-147. [15] 朱冬平,陈士贵,郭军.听觉统合治疗对听障患儿运动功能的影响[J].中国听力语言康复科学杂志,2020,18(3):219-222.
2023, Vol. 40 
