Abstract：【Objective】To explore the preventive effect of mecobalamin on peripheral neuropathy caused by XELOX regimen in patients with colorectal cancer. 【Methods】Ninety-two patients with colorectal cancer malignant tumors who were transferred to adjuvant chemotherapy after operation were randomly divided into the observation group( traditional XELOX+ Mecobalamin,n=46)and the control group ( traditional XELOX only,46 cases). Both groups took 21 days as a chemotherapy cycle and carried out at least 3 cycles. The nerve conduction velocity,incidence of acute and chronic toxicity, and the occurrence of other adverse reactions in the two groups were statistically compared between the two groups before chemotherapy and after 3 cycles of chemotherapy. 【Results】There was no significant difference in motor nerve conduction velocity between the two groups before and after chemotherapy (P>0.05). There was no significant difference in sensory nerve conduction velocity between the two groups before chemotherapy (P>0.05). After chemotherapy,the sensory nerve conduction velocity in the control group was lower than that before chemotherapy (P<0.05). There was no significant difference in the incidence of acute neurotoxicity between the two groups (P>0.05). After 1,2 and 3 cycles of chemotherapy,the incidence of chronic toxicity in the observation group was lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions such as nausea and vomiting,bone marrow suppression and general fatigue between the two groups (P>0.05). 【Conclusion】Mecobalamin can effectively prevent the effect of chemotherapeutic drugs on the sensory nerves of patients with colorectal cancer. It can also effectively prevent the chronic neurotoxicity caused by chemotherapeutic drugs,but it has no obvious effect on the acute neurotoxicity caused by chemotherapeutic drugs. Mecobalamin is safe,too.
2022, Vol. 39 
