Abstract：【Objective】To compare the quality of mixed concentrated platelets (platelet A),newly improved buffy coat mixed concentrated platelets (platelet B) and apheresis platelets (platelet C) and the effect of clinical infusion in patients with hematological diseases. 【Methods】The laboratory indexes of three platelet preparations were compared,which were divided into preventive infusion and therapeutic infusion according to the purpose of infusion. The platelet count,platelet correction index (CCI) and platelet recovery rate (PPR) before and after infusion were compared to judge the effect of preventive infusion. The blooding fraction before and after infusion was compared to judge the effect of therapeutic infusion,and the adverse transfusion reactions were statistically analyzed. 【Results】The number of platelets in platelet A were lower than that in platelet B and platelet C,the mixed amount of red blood cells (RBC) was higher than that in the other kinds of platelets. There were significant differences in the mixed number of leukocytes (WBC) of three platelet preparations if compared in between (all P<0.05). During preventive infusion,the platelet concentration before infusion in the same group was lower than that 24 hours after infusion,and the difference was statistically significant (all P<0.05). The platelet count 24 hours after infusion in platelet A was lower than that in platelet C,and the difference was statistically significant (P<0.05). There were 131 times of prophylactic infusions,whose infusion ineffective rate was 22.90%. The infusion ineffective rate of ITP patients (primary immune thrombocytopenia) was higher than that of other diseases,and the difference was statistically significant (all P<0.05). During therapeutic infusion,the bleeding fraction before infusion in the same group was higher than that 24 hours after infusion,and the difference was statistically significant (P<0.05). The bleeding fraction 24 hours after infusion in platelet A was significantly higher than that in the other two platelets (P<0.05). The adverse transfusion reaction rate in platelet A was higher than that in platelet C (P<0.05). 【Conclusion】Some laboratory indexes of infusion effect and adverse transfusion reaction rate in platelet C and platelet B were better than those in platelet A. The platelet B could be used as an effective supplement when the supply of apheresis platelets was insufficient.
熊志高, 李彦勋, 程金凤, 贺锋. 三种血小板制剂质量比较及对血液病患者输注的效果[J]. 医学临床研究, 2022, 39(6): 819-822.
XIONG Zhi-gao, LI Yan-xun, CHENG Jin-feng,et al. Quality Comparison of Three Platelet Preparations and Evaluation of Transfusion Effects in Patients with Hematological Diseases. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 819-822.
2022, Vol. 39 
