Abstract：【Objective】To explore the diagnostic value of the serum chitinase 3-like protein 1 (CHI3L1) level and Fibroscan in patients with liver fibrosis. 【Methods】A total of 392 outpatients and inpatients in the Department of Liver Diseases of Hunan Provincial People's Hospital from September 2018 to December 2019 were collected. Fibroscan was used to measure liver elasticity (LS). LS value ≤7.3 kPa was included in the non-fibrosis group (n=115), LS value ≤17.4 kPa was included in the fibrosis group (n=85), and LS value ≥17.5 kPa was included in the cirrhosis group group (n=192).Enzyme-linked immunosorbent assay (ELISA) was used to detect serum CHI3L1 levels in all subjects, an automatic biochemical analyzer was used to determine patient liver function indexes (ALT, AST, TBIL, DBIL, TP, ALB), and Fibroscan was used to determine liver stiffness (LS). The correlation between CHI3L1 and liver function indexes was analyzed and the ROC curve of serum CHI3L1 level and LS value in the diagnosis of liver fibrosis patients was drawn.【Results】The clinical data of the three groups of patients were compared, and the difference of age, BMI, combined drinking history were statistically significant (P<0.05). The CHI3L1, LS, liver function indexes (ALT, AST, TBIL, DBIL, TP, ALB) of each group were compared, and the differences were statistically significant (P<0.05). The level of CHI3L1 in the non-fibrosis group was not correlated with various liver function indexes and LS values (P>0.05). The level of serum CHI3L1 in the fibrosis group was not correlated with various liver function indexes (P>0.05), but positively correlated with LS (P<0.05). Serum CHI3L1 level in the cirrhosis group was positively correlated with ALT and LS, negatively correlated with ALB (P<0.05), and not correlated with AST, TBIL, DBIL, TP (P>0.05). The area under curve of the serum CHI3L1 and LS value are 0.841 and 0.717, respectively. Both methods have high diagnostic efficiency for patients with liver fibrosis, and the diagnostic efficiency of serum CHI3L1 is slightly higher than the LS value. 【Conclusion】Serum CHI3L1 levels are closely related to liver function indexes such as ALT and ALB, and can reflect early liver damage. Compared with Fibroscan, it has higher diagnostic efficiency in patients with liver fibrosis and is worthy of clinical promotion.
毛卓, 廖爱军, 廖金卯, 胡小宣. 血清壳多糖酶3样蛋白1水平与肝脏弹性值测定对肝纤维化诊断价值的比较[J]. 医学临床研究, 2021, 38(6): 806-810.
MAO Zhuo, LIAO Ai-jun, LIAO Jin-mao, et al. Comparison of the Diagnostic Value of Serum Chitinase 3-like Protein 1 Level and Liver Elasticity in the Diagnosis of Liver Fibrosis. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 806-810.
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2021, Vol. 38 
