Abstract：【Objective】To investigate the expression level and significance of thyrotropin (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in serum of patients with diffuse goiter with hyperthyroidism Graves Disease. 【Methods】A total of 130 Graves patients (observation group) treated in our hospital from January 2017 to June 2018 were selected, and 100 healthy volunteers were selected as control group, serum TSH, TPOAb and TGAb levels were measured. 【Results】 The level of TSH in the observation group was significantly lower than that in the control group, while the level of TPOAb and TGAb in the observation group was significantly higher than that in the control group, and the differences were statistically significant (P<0.05); the level of TSH, TPOAb and TGAb in the observation group with and without exophthalmos had no statistically significant difference (P>0.05). In the observation group, there were 33 patients with hypothyroidism 6 months after treatment; the levels of TPOAb and TGAb in patients with early-onset hypothyroidism before treatment were significantly higher than those in patients without hypothyroidism (P<0.05). 【Conclusion】The serum levels of TSH, TPOAb and TGAb were significantly abnormal in patients with Graves' disease. The levels of TPOAb and TGAb before treatment may be related to the occurrence of hypothyroidism after treatment, but the levels of TSH, TPOAb and TGAb have no significant relationship with the presence of exophthalmos.
薛乐, 蔡若蓓. TSH、TPOAb、TGAb在Graves病患者血清中的表达水平及其意义[J]. 医学临床研究, 2020, 37(12): 1805-1807.
XUE Le, CAI Ruo-bei. Expression and Significance of TSH, TPOAb and TGAb in Serum of Patients with Graves' Disease. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1805-1807.
[1] 谢谦, 张帆, 吴嘉,等. Graves病患者血清B细胞活化因子和增殖诱导配体水平检测及其临床意义分析[J].医学临床研究,2012,29(6):1117-1119. [2] Bell L, Hunter AL, Kyriacou A, et al. Clinical diagnosis of Graves’ or non-Graves’ hyperthyroidism compared to TSH receptor antibody test[J].Endocr Connect,2018,7(4):504-510. [3] Seo S, Sánchez Robledo M. Usefulness of TSH receptor antibodies as biomarkers for Graves’ ophthalmopathy: a systematic review[J].J Endocrinol Invest,2018,41(12):1457-1468. [4] 郑款恒,雷新键,张水英. 联合检测抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体在判断甲状腺癌术后复发或转移中的价值[J].中国临床医生杂志,2017,45(4):72-74. [5] 程歆琦,金成,韩松,等. 甲状腺球蛋白自身抗体对2种化学发光免疫学方法检测甲状腺球蛋白的影响[J].中华检验医学杂志,2015,38(10):701-704. [6] 刘刚,焦华杰,杜婧,等.磁共振眼眶脂肪定量测量联合眼球突出度在Graves眼病的诊断价值[J].实用放射学杂志,2020,36(5):710-713. [7] Diana T, Daiber A, Oelze M, et al. Stimulatory TSH-receptor antibodies and oxidative stress in Graves disease[J].J Clin Endocrinol Metab,2018,103(10):3668-3677. [8] 吴娜,孙丰源,李佳,等. 甲状腺相关眼病患者血清TRAb、TPOAb、TGAb水平变化及意义[J].山东医药,2015,55(30):59-60. [9] 张丽,白超,杨雯雯. 桥本甲状腺炎合并甲状腺癌的临床特征分析[J].中国医师进修杂志,2016,26(4):299-302. [10] Siderova M, Hristozov K, Tsukeva A. TSH-receptor antibodies may prevent bone loss in pre- and postmenopausal women with Graves' disease and Graves' orbitopathy[J].Arch Endocrinol Metab,2018,62(2):221-226. [11] 王波,孟佳慧. 甲状腺自身抗体对Graves病及桥本甲状腺炎诊断的研究[J].中国实验诊断学,2018,22(2):207-209.
2020, Vol. 37 
