Abstract：【Objective】 To investigate the effects of ultrasound-guided never block on postoperative visual analogue pain score (VAS), serum serotonin (5-HT), β-endorphin (β-EP), plasma substance P (SP) and interleukin 6 (IL-6) in patients undergoing total knee arthroplasty (TKA). 【Methods】 Ninety patients with lower extremity nerve block TKA in our hospital were randomly divided into two groups with 45 cases each. The experimental group was treated with ultrasound-guided nerve block analgesia and the control group was treated with intra-injection of analgesic drugs. The VAS scores of the patients at rest and activity within 48 hours after operation were compared between the two groups. The serum 5-HT, β-EP, SP, IL-6 were compared between the preoperative and postoperative 24h. 6 levels. 【Results】 No matter of resting and active states, the VAS scores of patients in the experimental group at 6h, 12h, 24h, 48h after operation were lower than those in the control group at the corresponding time points. The differences were statistically significant (P<0.05). Before operation, the serum of levels of EP, SP and IL-6 the two groups were no significant differences (P>0.05). The serum SP and IL-6 levels in the experimental group at 24h after surgery were lower, while the levels of 5-HT and β-EP were significantly higher than those in the control group (P<0.05). 【Conclusion】 Ultrasound-guided nerve block has better analgesic effects on TKA patients through regulating the release of pain-related factors in patients.
刘金龙, 吕宝胜, 陈欢, 王佳璐. 超声引导下神经阻滞对全膝关节置换患者术后VAS评分、血清疼痛介质的影响[J]. 医学临床研究, 2020, 37(10): 1465-1467.
LIU Jin-long, LV Bao-sheng, CHEN Huan, et al. Effect of Ultrasound-guided Nerve Block on Postoperative VAS Score and Serum Pain Mediator in Patients with Total Knee Arthroplastry. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1465-1467.
2020, Vol. 37 
