Abstract：【Objective】To investigate the clinical characteristics of patients with chronic kidney disease complicated with metabolic syndrome (MS).【Methods】A total of 164 patients with chronic kidney disease were divided into two groups: MS group (group A) and non-MS group (group B). Patients were furthermore put in three groups (Ⅰ,Ⅱ and Ⅲ) according to the amount of urine protein. Fasting blood glucose (FBG), triacylglycerol (TG), serum creatinine (SCr), blood uric acid (UA), and high-density lipoprotein (HDL-C), estimate glomerular filtration rate (eGFR), body mass index (BMI), urine protein, systolic and diastolic blood pressure were recorded. The incidence of MS in patients with different urinary protein content was observed and compared. Multivariate regression analysis was performed on the factors that may affect the urine protein content. 【Results】Among 164 patients, 62 patients in group A had MS, accounting for 37.80%; 102 patients in group B had no MS, accounting for 62.20%. The levels of systolic blood pressure , diastolic blood pressure, FBG,TG,SCr,UA,BMI and urine protein in group A were higher than those in group B, while levels of HDL-C and eGFR in group A were lower than those in group B (P<0.05). With increasing urinary protein content, the eGFR of patients in group Ⅰ,Ⅱ and Ⅲ gradually decreased. The eGFR of group Ⅰ was significantly higher than that of group Ⅱ and group Ⅲ (P<0.05). Systolic blood pressure , diastolic blood pressure, FBG , TG、HDL-C、SCr、BMI and MS incidence rate in group Ⅰ were lower than those in group Ⅱ and Ⅲ (P<0.05). Increased waist-to-hip ratio was the only independent risk factor for the occurrence of moderate proteinuria, while mildly elevated blood glucose, increased TG/HDL-C ratio, advanced age and increased waist-to-hip ratio were independent risk factors for the development of massive proteinuria.【Conclusion】Patients with chronic kidney disease patients have a high rate of metabolic syndrome. Fasting blood glucose, increased waist-to-hip ratio and dyslipidemia are independent risk factors for the development of massive proteinuria in patients with chronic kidney disease. Therefore, early intervention of MS can effectively delay the progression of chronic kidney disease.
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2020, Vol. 37 
