Abstract：To explore the changes of serum levels of inflammatory factors human cartilage glycoprotein(YKL-40) and human pentraxins(PTX-3) in patients with essential hypertension(EH) and their correlation with metabolic syndrome(MS) .[Methods]Totally 60 EH patients and 39healthy subjects were en-rolled in this study . Serum levels of YKL-40 and PTX-3 were measured by using enzyme immunoassay (ELISA) .According to hypertension with or without MS ,all patients were divided into hypertension with MS group( n=23) and simple hypertension group( n=37) .Serum levels of YKL-40 and PTX-3 among hyperten-sion with MS group ,simple hypertension group and healthy control group were compared .[Results] Serum levels of YKL-40 in hypertension groups were obviously higher than those in healthy control group [(54 .3 ± 29 .0ng/mL) vs .(27 .2 ± 8 .7ng/mL) ,P<0 .05] ,while there was no significant difference in PTX-3 between two groups( P<0 .05) .Serum levels of YKL-40 in hypertension with MS group were higher than those in simple hypertension group[(69 .2 ± 35 .9μg/L) vs .(45 .1 ± 19 .1μg/L) ,P<0 .05] .YKL-40 was significantly correlated with systolic pressure ,diastolic pressure ,leukocyte number and PTX-3( r = 0 .341 ,0 .268 ,0 .299 and 0 .371 ,P <0 .05) ,and PTX-3 was correlated with heart rate ,serum uric acid and serum creatinine( r =0 .209 ,0 .206 and 0 .242 ,P<0 .05) .[Conclusion]Inflammatory factor YKL-40 in patients with hypertension is increased ,which suggests that YKL-40 may participate in the pathophysiological process of EH .YKL-40 for blood pressure control and prognosis evaluation in patients with hypertension is better than PTX-3 .
2014, Vol. 31 
