Abstract：Objective This aim was to investigate the relationship between cognitive function and serum levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy) and Cys C in patients with senile dementia (Alzheimer's disease). Methods A total of 106 patients with senile dementia admitted to our hospital from June 2014 to October 2017 were selected in the study. According to MMSE score, patients were divided into two groups: Alzheimer's disease (AD,n=59) and mild cognitive impairment (MCI, n=47). Meanwhile, 40 healthy subjects with matched health and education status in the same period were selected as the control group. Logistic regression analysis was used to analyze the relationship between the risk of dementia and serum indexes. Results The levels of Hcy and hs-CRP were AD group > MCI group > the control group (P<0.05). Cys C level order was AD group < MCI group < the control group (P<0.05). The level of IL-6 seemed to show AD group > MCI group > the control group. However, the differences were not statistically significant (P<0.05). The serum levels of IL-6, hs-CRP, Hcy and Cys C in AD patients were not significantly correlated with MMSE scores (P>0.05). The prevalence of AD is associated with levels of low folate, high hs-CRP and high Hcy. Conclusion The results show that there is no significant correlation between cognitive function and serum levels of IL-6, hs-CRP, Hcy and Cys C in patients with Alzheimer's disease. Low folate, high Hcy levels and high hs-CRP levels may increase the risk of AD by some mechanism. Cys C may be protective factors of cognitive impairment in AD.
郭敏, 金迪, 王培福, 李继来. 阿尔茨海默病患者认知功能与其血清IL-6、hs-CRP、Hcy、Cys C水平相关性分析[J]. 医学临床研究, 2019, 36(2): 284-284.
GUO Min, JIN Di, WANG Pei-fu, et al. Analysis of Correlation between Cognitive Function and Levels of IL-6, hs-CRP, Hcy and Cys C in Patients with Senile Dementia. JOURNAL OF CLINICAL RESEARCH, 2019, 36(2): 284-284.
[1] Hsu WY, Ku Y, Zanto TP,et al. Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis[J].Neurobiol Aging,2015,36(8):2348-2359. [2] Holz MR, Kochhann R, Ferreira P, et al. Cognitive performance in patients with Mild Cognitive Impairment and Alzheimer's disease with white matter hyperintensities: an exploratory analysis[J].Dement Neuropsychol,2017,11(4):426-433. [3] 王华丽, 彭华茂.认知训练应用于老年轻度认知损害的几点思考[J].中华内科杂志,2017,56(2):92-93. [4] 孙芹敏, 王哲, 曲梦琦, 等.老年痴呆患者血清同型半胱氨酸水平及临床意义[J].中国老年学杂志,2015,35(7):1729-1731. [5] Insel PS, Hansson O, Mackin RS, et al. Amyloid pathology in the progression to mild cognitive impairment[J].Neurobiol Aging,2018,64:76-84. [6] Cramer PE, Gentzel RC, Tanis KQ, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease[J].Neurobiol Aging,2017,64:92-106. [7] 田华, 王红灵.血清同型半胱氨酸、叶酸及维生素B12与老年血管性痴呆的相关性研究[J].中国基层医药,2014,21(7):982-984. [8] Kosenko EA, Tikhonova LA, Montoliu C, et al. Metabolic abnormalities of erythrocytes as a risk factor for Alzheimer's disease[J].Front Neurosci,2018,11:728.
2019, Vol. 36 
