Abstract：【Objective】To investigate the relationship between serum cystatin C(Cys C) level and cognitive impairment in elderly patients with Type 2 Diabetes Mellitus. 【Methods】A total of 100 elderly patients with type 2 diabetes were selected and divided into the high Cys C group and low Cys C group according to their levels of cystatin C. The differences of clinical characteristics and the scale of elderly cognitive function (SECF) scores between the two groups were compared. Logistic regression was used to analyze the correlation between the level of Cys C and cognitive dysfunction. 【Results】There were statistically significant differences between the two groups in the total score of SECF and its subdivisions: orientation, width, animal name, calculation, classification, copying, speech and memorization (P<0.05). Comparing the ratio of abnormal case numbers in each item, the differences in total score, orientation, memorization, animal name, calculation, copying and speech were statistically significantly different (P<0.05). Univariate logistic regression analysis showed that the OR value of cognitive dysfunction in high Cys C group was 2.538 compared with that in low Cys C group. However, multivariate logistic regression analysis showed age, male, uric acid were independent risk factors for cognitive impairment; Cys C did not enter the equation. 【Conclusion】 The level of serum Cys C may be associated with cognitive dysfunction in elderly patients with type 2 diabetes, but is not independently related.
黄迪迪, 陈露文, 王新洁, 覃苑. 胱抑素C与老年2型糖尿病患者认知功能障碍的关系[J]. 医学临床研究, 2018, 35(6): 1050-1052.
HUANG Di-di, CHENLu-wen, WANG Xin-jie, et al. Relationship between Cystatin C and Cognitive Dysfunction in Elderly Patients with Type 2 Diabetes Mellitus. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1050-1052.
[1] Zhong XM, Hou L, Luo XN,et al. Alterations of CSF cystatin C levels and their correlations with CSF Alphabeta40 and Alphabeta42 levels in patients with Alzheimer's disease, dementia with Lewy bodies and the atrophic form of general paresis[J].PLoS One,2013,8(1):e55328.
[2] Paterson RW,Bartlett JW,Blennow K,et al.Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals[J].Transl Psychiatry,2014, 4:e419.
[3] Riverol M, Becker JT, López, OL,et al.Relationship between systemic and cerebral vascular disease and brain structure integrity in normal elderly individuals[J].J Alzheimers Dis,2015, 44(1): 319-328.
[4] Grewa lR, Haghighi M, Huang S,et al.Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients[J].Alzheimer's Res Ther,2016, 8(1):43.
[5] Wei Yd,Wei YK,Zhu JM.Early markers of kidney dysfunction and cognitive impairment amongolder adults[J].J Neurol Sci,2017,375:209-214.
[6] Casado-Naranjo I, Portilla-Cuenca JC, De San Juan B,et al.Association of vascular factors and amnestic mild cognitive impairment:A comprehensive approach[J].J Alzheimers Dis,2015,44(2): 695-704.
[7] Yaffe K,Kurella-Tamura M,Ackerson L, et al. .Higher levels of cystatin c are associated with worse cognitive function in older adults with chronic kidney disease: The chronic renal insuffciency cohort cognitive study[J].J Am Geriatr Soc,2014,62:1623-1629.
[8] Hu WD,Chen J,Mao CJ,et al. Elevated cystatin C levels are associated with cognitive impairment and progression of parkinson disease[J].Cogn Behav Neurol,2016,29(3):144-149.
[9] Murray AM,Barzilay JI,Lovato JF,et al.Biomarkers of renal function and cognitive impairment in patients with diabetes[J] .Diabetes Care,2011,34(8):1827-1832.
[10] Alosco ML,Spitznagel MB,Strain G,et al.The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months: after bariatric surgery[J].J Neurol Sci,2014 , 345(1-2): 176-180.
[11] Slinin Y,Peters KW,Ishani A,et al.Cystatin C and cognitive impairment 10 years later in older women[J].J Gerontol A Biol Sci Med Sci,2015, 70(6):771-778.
2018, Vol. 35 
