Abstract：【Objective】To investigate the clinical effect of sequential interventional therapy for colorectal liver metastases of colorectal cancer and to explore an effective treatment for improving the prognosis.【Methods】A total of 126 colorectal cancer patients with liver metastasis who were treated in our hospital from October 2013 to October 2016 were selected as study subjects. According to the different treatment methods, they were divided into a routine chemotherapy group and sequential interventional therapy group, with 63 cases in each group. Patients in chemotherapy group received FOLFOX chemotherapy while patients in the sequential intervention group were treated with radiofrequency catheter ablation (TACE) and radiofrequency catheter ablation (RFA) at the third month and the sixth month after they developed liver metastases, followed by iodized oil emulsifier embolization via catheterization at the end of chemotherapy. The therapeutic effect, side effects and survival rate of the two groups were then compared.【Results】The proportion of complete remission (CR) and partial remission (PR) in the sequential intervention group was significantly higher than that in the chemotherapy group, and the disease progression (PD) rate was significantly lower than that in the chemotherapy group. The treatment efficacy rate of the sequential intervention group was significantly higher than that of the chemotherapy group (P<0.05); The rate of positive serum alpha-fetoprotein (AFP) returning to normal level in the sequential intervention group was higher than that in the chemotherapy group (P<0.05).The no change rate and increasing rate of AFP in sequential intervention group were significantly lower than those in the chemotherapy group (P<0.05); there was no difference in the serum descending rate (P>0.05). The 6-month, 12-month survival rate and median survival time in the sequential intervention group were significantly higher than those in the chemotherapy group (P<0.05); There was no significant difference in the incidence of side effects between the two groups (25.4% vs 20.63%, χ2=0.224, P=0.636;P>0.05).【Conclusion】Sequential interventional therapy in unresectable colorectal cancer patients with live metastasis is a reliable treatment method. It can extend the survival time of patients and reduce the adverse effects of chemotherapy. It is worth promoting sequential interventional therapy in clinical application.
2018, Vol. 35 
