医学临床研究
  2025年4月6日 星期日           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2018, Vol. 35 Issue (10): 1877-1879    DOI: 10.3969/j.issn.1671-7171.2018.10.002
  论著 本期目录 | 过刊浏览 | 高级检索 |
替加环素治疗碳青霉烯类抗生素耐药肺炎克雷伯菌所致医院获得性肺炎的疗效观察
谭建龙a, 刘志光a, 谢良伊b, 张卫东a**
湖南省人民医院/湖南师范大学第一附属医院:a.呼吸内科;b.检验科,湖南 长沙 410005
Efficacy and Safety of Tigecycline in Treatment of Hospital Associated Pneumonia(HAP) Caused by Carbapenem-resistant Klebsiella(CRKP)
TAN Jian-long, LIU Zhi-guang, XIE Liang-yi, et al
Department of Respiratory Medicine,Hunan Provincial People's Hospital /the First Affiliated Hospital of Hunan Normal University, Changsha , Hunan 410005
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】探讨替加环素治疗碳青霉烯类抗生素耐药肺炎克雷伯菌(CRKP)所致医院获得性肺炎(HAP)的疗效与安全性。【方法】对本院2010年9月至2013年3月收治的22例痰或肺泡灌洗液培养提示CRKP感染的 HAP患者,使用替加环素治疗,疗程至少5 d。回顾性分析患者的临床疗效、细菌学疗效以及不良反应。【结果】22例患者中,临床痊愈6例(27.27%),4例显效,有效率为45.45%(10/22);细菌清除12例,清除率为54.55%(12/22)。高剂量组和低剂量组临床有效率及细菌清除率比较差异无统计学意义(χ2=1.473,P=0.225;χ2=0.321,P=0.571);联用碳青霉烯类抗生素组和联用非碳青霉烯类抗生素组的临床有效率及细菌清除率比较差异无统计学意义(χ2=0.028,P=0.867;χ2=0.566,P=0.452)。22例患者中2例(9.1%)出现恶心、呕吐,经对症处理后症状消失,未停药;2例出现转氨酶水平升高,经护肝治疗后降至正常,未停药;治疗过程中2例出现二重感染,1例(9.1%)出现铜绿假单胞菌感染,1例(9.1%)出现嗜麦芽窄食假单胞菌,根据药敏选择联合用药,未发生严重不良事件。【结论】替加环素可作为CRKP感染所致医院获得性肺炎的一种治疗选择,但尚需要积累更多临床经验,尤其迫切需要大样本前瞻性研究,以探讨常规剂量及高剂量治疗的疗效及安全性。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
谭建龙
刘志光
谢良伊
张卫东
关键词 克雷伯菌, 肺炎/药物作用药用制剂    
Abstract:【Objective】To retrospectively analyze the efficacy and safety of Tigecycline in treatment of hospital associated pneumonia(HAP) caused by carbapenem-resistant Klebsiella(CRKP). 【Methods】 From September 2010 to March 2013, 22 patients with HAP infected by CRKP through sputum or alveolar lavage fluid culture were admitted to our hospital. Tegacycline was used for at least 5 days. Clinical efficacy, bacteriological efficacy and adverse reactions were retrospectively analyzed. 【Results】Among the 22 patients, 6 cases (27.27%) were cured, 4 cases were effective, the effective rate was 45.45% (10 / 22), and the clearance rate of bacteria was 54.55% (12 / 22). There was no significant difference in the clinical effective rate and bacterial clearance rate between the high dose group and the low dose group(χ2=0.028,P=0.867;χ2=0.566,P=0.452). There was no significant difference in the clinical effective rate and bacterial clearance rate between the carbapenem antibiotics group and the non-carbapenem antibiotic group(χ2=0.028,P=0.867;χ2=0.566,P=0.452). Of the 22 patients, 2 (9.1%) developed nausea and vomiting, and the symptoms disappeared after symptomatic treatment,the drug was not stopped. In the course of treatment, there were 2 cases of double infection, 1 case (9.1%) of Pseudomonas aeruginosa and 1 case (9.1%) of Pseudomonas maltophilia, and according to drug sensitivity, no serious adverse events occurred. 【Conclusion】Tegacycline can be used as a therapeutic option for HAP caused by CRKP infection. However, it is necessary to accumulate more clinical experience, especially for a large sample of prospective studies to explore the efficacy and safety of conventional and high dose therapy.
Key wordsKlebsiella pneumoniae/DE    Pharmaceutical Preparations
收稿日期: 2017-12-26     
PACS:  R563.11  
基金资助:湖南省卫生计生委科研计划课题项目(B2016006);湖南省人民医院仁术基金(2013-34)
通讯作者: **Email:700816@sina.com   
引用本文:   
谭建龙, 刘志光, 谢良伊, 张卫东. 替加环素治疗碳青霉烯类抗生素耐药肺炎克雷伯菌所致医院获得性肺炎的疗效观察[J]. 医学临床研究, 2018, 35(10): 1877-1879.
TAN Jian-long, LIU Zhi-guang, XIE Liang-yi, et al. Efficacy and Safety of Tigecycline in Treatment of Hospital Associated Pneumonia(HAP) Caused by Carbapenem-resistant Klebsiella(CRKP). JOURNAL OF CLINICAL RESEARCH, 2018, 35(10): 1877-1879.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2018.10.002     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2018/V35/I10/1877
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn