Effects of Citrus Flavone Combined with Diosmin on Perianal Edema, Pain Degree and Clinical Efficacy in Patients with Circular Mixed Hemorrhoids after Surgery
SHEN Jianzhong
Department of General Surgery Ⅰ, the Fourth People's Hospital of Zhumadian, Zhumadian Henan 463000
Abstract：【Objective】 To explore the effects of citrus flavone combined with diosmin on postoperative perianal edema, pain degree and clinical efficacy in patients with circular mixed hemorrhoids. 【Methods】 A total of 90 patients with circular mixed hemorrhoids admitted to our hospital from February 2022 to February 2025 were selected and divided into the control group and the observation group by random number table method, with 45 cases in each group. The control group received oral diosmin tablets after surgery, while the observation group was treated with oral diosmin tablets combined with citrus flavone tablets after surgery. The perianal edema degree, pain degree and clinical efficacy of the two groups were compared on the 1st and 7th day after operation. 【Results】 On the 7th day after surgery, the perianal edema scores of both groups were lower than those on the 1st day after surgery, and the observation group had significantly lower scores than the control group (P<0.05). Similarly, the Visual Analogue Scale (VAS) scores of the two groups on the 7th day after surgery were lower than those on the 1st day after surgery, and the observation group was superior to the control group (P<0.05). The total clinical effective rate of the observation group was 97.78% (44/45), which was significantly higher than 77.78% (35/45) of the control group (χ2=8.389, P<0.05). 【Conclusion】 The combination of citrus flavone and diosmin can effectively relieve postoperative perianal edema and pain in patients with circular mixed hemorrhoids, with favorable clinical efficacy, which is worthy of clinical promotion and application.
申建中. 柑橘黄酮联合地奥司明对环状混合痔患者术后肛缘水肿、疼痛程度及临床疗效的影响[J]. 医学临床研究, 2026, 43(6): 945-947.
SHEN Jianzhong. Effects of Citrus Flavone Combined with Diosmin on Perianal Edema, Pain Degree and Clinical Efficacy in Patients with Circular Mixed Hemorrhoids after Surgery. JOURNAL OF CLINICAL RESEARCH, 2026, 43(6): 945-947.
[1] 周寒璞,杨巍,陈天,等. TST联合术式治疗环状混合痔的应用现状[J].结直肠肛门外科,2023,29(3):317-320. [2] SUN X W, XU J Y, ZHU C Z, et al. Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids: a retrospective study[J].World J Gastrointest Surg,2024, 16(3): 731-739. [3] 廖宁,龚绍江,刘海林. 槐榆清热止血胶囊联合地奥司明治疗混合痔的临床研究[J].现代药物与临床,2025,40(3):703-707. [4] 杨周雨,钟培,李可,等. 生肌玉红膏联合柑橘黄酮片对混合痔术后患者肛门功能、创面恢复及创面组织的影响[J].中国药业,2025,34(7):101-104. [5] 中国中西医结合学会大肠肛门病专业委员会. 中国痔病诊疗指南(2020)[J].结直肠肛门外科,2020,26(5):519-533. [6] CHOINIÈRE M,AMSEL R. A visual analogue thermometer for measuring pain intensity[J].J Pain Symptom Manage,1996,11(5):299-311. [7] LIU X, SHENG B, ZHANG J B, et al. Modified whitehead hemorrhoidectomy versus partial hemorrhoidectomy for fourth-degree circular mixed hemorrhoids: a retrospective analysis[J].Heliyon,2024, 10(7): e28465. [8] 敬秀平, 陈显韬. 环状混合痔手术治疗研究进展[J].中国肛肠病杂志, 2019, 39(9): 75-76. [9] 程涛,滕向龙,饶志杰,等. 复方荆芥熏洗剂辅助外剥内扎术治疗混合痔临床研究[J].新中医,2023,55(4):82-85. [10] AWAD N, HETZEL J D, BHUPALAM V, et al. Stasis dermatitis: pathophysiology, current treatment paradigms, and the use of the flavonoid diosmin[J].J Clin Aesthet Dermatol,2024, 17(1): 15-23. [11] FANG Y Y, XIANG W, CUI J W, et al. Anti-inflammatory properties of the Citrus Flavonoid Diosmetin: an updated review of experimental models[J].Molecules,2024, 29(7): 1521. [12] 戴阳义, 汤华, 邬思元, 等. 柑橘黄酮片联合五倍子汤熏洗治疗炎性外痔临床观察[J].药品评价, 2023, 20(10): 1260-1263. [13] 陈邦合,毛细云,王宏昌,等. 五倍子汤联合地奥司明对肛瘘手术患者疼痛、创面愈合情况及肛门括约肌功能的影响[J].中国医院用药评价与分析,2024,24(12):1469-1471. [14] ZULKEFLI N, CHE ZAHARI C N M, SAYUTI N H, et al.Flavonoids as potential wound-healing molecules: Emphasis on pathways perspective[J].Int J Mol Sci,2023, 24(5): 4607.
2026, Vol. 43 
