Clinical Efficacy of Compound Intestinal Microecological Preparation Combined with Modified Low-Carbon Diet in the Treatment of Children with Simple Obesity
LU Xinjie, CAI Yingqing, ZHANG Haili, WU Huiying
Yangzhou University Affiliated Nantong Rich Hospital,Nantong Jiangsu 226001
Abstract：【Objective】 To explore the clinical efficacy of compound intestinal microecological preparation combined with modified low-carbon diet in the treatment of children with simple obesity. 【Methods】 A total of 108 children with simple obesity admitted to our hospital from January 2022 to August 2024 were selected and divided into an observation group and a control group, with 54 cases in each group according to different treatment methods. All children in both groups received motor behavior intervention. The control group was intervened with simple energy-restricted balanced diet, while the observation group was intervened with compound intestinal microecological preparation combined with modified low-carbon diet. Both groups were treated for 6 weeks. Blood lipid indexes [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], glucose metabolism indexes [fasting plasma glucose (FPG), fasting insulin (FINS), insulin resistance index (HOMA-IR)], physical and blood pressure indexes [body weight, body fat percentage, systolic blood pressure (SBP) and diastolic blood pressure (DBP)], adipocytokines [leptin, adiponectin, visfatin] and gastrointestinal adverse reactions were compared between the two groups before and after intervention. 【Results】 After intervention, the levels of TC, TG and LDL-C in both groups were lower than those before intervention, and the level of HDL-C was higher than that before intervention. Moreover, the levels of TC, TG and LDL-C in the observation group were lower than those in the control group, and the level of HDL-C was higher than that in the control group, with statistically significant differences (P<0.05). After intervention, the body weight, body fat percentage, SBP and DBP in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After intervention, the levels of FPG, FINS and HOMA-IR in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After intervention, the levels of leptin and visfatin in both groups were lower than those before intervention, and the level of adiponectin was higher than that before intervention. Furthermore, the levels of leptin and visfatin in the observation group were lower than those in the control group, and the level of adiponectin was higher than that in the control group, with statistically significant differences (P<0.05). After intervention, the incidence of constipation in the observation group was lower than that before intervention and lower than that in the control group, with a statistically significant difference (P<0.05). There were no statistically significant differences in the incidences of diarrhea and abdominal pain between the two groups (P>0.05). 【Conclusion】 Compound intestinal microecological preparation combined with modified low-carbon diet can regulate glycolipid metabolism and improve physical indexes in children with simple obesity.
陆新杰, 蔡迎庆, 张海丽, 吴卉颖. 复合肠道微生态制剂联合改良低碳饮食治疗单纯性肥胖儿童的临床疗效[J]. 医学临床研究, 2026, 43(3): 371-374.
LU Xinjie, CAI Yingqing, ZHANG Haili, WU Huiying. Clinical Efficacy of Compound Intestinal Microecological Preparation Combined with Modified Low-Carbon Diet in the Treatment of Children with Simple Obesity. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 371-374.
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2026, Vol. 43 
