在常规治疗的基础上联合达格列净与芪苈强心胶囊治疗慢性心力衰竭心肾阳虚证患者的临床效果

doi:10.3969/j.issn.1671-7171.2026.04.012

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摘要 【目的】探讨在常规治疗的基础上联合达格列净与芪苈强心胶囊治疗慢性心力衰竭(CHF)心肾阳虚证患者的临床效果。【方法】回顾性分析2022年1月至2024年12月上海市静安区市北医院收治的120例CHF心肾阳虚证患者的临床资料,根据治疗方法的不同分为对照组(在常规治疗的基础上口服达格列净片)和观察组(在对照组基础上口服芪苈强心胶囊),每组60例。比较两组心功能指标[左室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI)]、中医证候积分及不良反应发生情况。【结果】治疗后,两组LVEF、SV、CI均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组主证积分、次证积分、总积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组、对照组不良反应总发生率分别为8.33%(5/60)、6.67%(4/60),两组不良反应总发生率比较,差异无统计学意义(χ²=0.12,P=0.729)。【结论】在常规治疗的基础上联合达格列净与芪苈强心胶囊治疗CHF心肾阳虚证患者,可显著改善患者的临床症状,缓解其临床症状,且安全性良好。

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	蔡明慧
	郑婷
	王艳
	徐玉萍

关键词 ：心力衰竭, 慢性病, 药物疗法, 联合, 强心药(中药), 治疗结果

Abstract：【Objective】 To investigate the clinical effect of combining dapagliflozin and Qili Qiangxin Capsule on conventional therapy for chronic heart failure (CHF) with heart-kidney yang deficiency syndrome. 【Methods】 Clinical data of 120 patients with CHF and heart-kidney yang deficiency syndrome admitted to Shibei Hospital of Jing'an District from January 2022 to December 2024 were retrospectively analyzed. Patients were divided into a control group (receiving oral dapagliflozin based on conventional therapy, n=60) and an observation group (receiving oral Qili Qiangxin Capsule in addition to the control group regimen, n=60) according to different treatment methods. Cardiac function indicators [left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac index (CI)], traditional Chinese medicine (TCM) syndrome scores, and adverse reactions were compared between the two groups. 【Results】 After treatment, LVEF, SV, and CI in both groups were higher than before treatment, and these indicators in the observation group were higher than those in the control group, with statistically significant differences (P<0.05). After treatment, the primary syndrome scores, secondary syndrome scores, and total scores in both groups were lower than before treatment, and the scores in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The total incidence of adverse reactions was 8.33% (5/60) in the observation group and 6.67% (4/60) in the control group, with no statistically significant difference between the two groups (χ²=0.12,P=0.729). 【Conclusion】 Combining dapagliflozin with Qili Qiangxin Capsule in addition to conventional therapy can significantly improve cardiac function and alleviate clinical symptoms in patients with CHF and heart-kidney yang deficiency syndrome, with a favorable safety profile.

Key words： Heart Failure Chronic Disease Drug Therapy, Combination Cardiotonic Agents (TCD) Treatment Outcome

收稿日期: 2025-11-27

中图分类号:

R542.22

通讯作者: ^*E-mail:775761437@qq.com

引用本文:

蔡明慧, 郑婷, 王艳, 徐玉萍. 在常规治疗的基础上联合达格列净与芪苈强心胶囊治疗慢性心力衰竭心肾阳虚证患者的临床效果[J]. 医学临床研究, 2026, 43(4): 570-572.
CAI Minghui, ZHENG Ting, WANG Yan, XU Yuping. Clinical Effect of Combining Dapagliflozin and Qili Qiangxin Capsule on Conventional Therapy for Chronic Heart Failure with Heart-Kidney Yang Deficiency Syndrome. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 570-572.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.04.012 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I4/570

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