榄香烯联合洛铂治疗肺癌性胸腔积液患者的疗效

doi:10.3969/j.issn.1671-7171.2026.01.020

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摘要 【目的】 探讨榄香烯联合洛铂治疗肺癌性胸腔积液患者的疗效。【方法】 133例肺癌性胸腔积液患者,随机分为观察组(66例)和对照组(67例)。对照组在常规治疗基础上给予洛铂治疗,观察组在对照组基础上给予洛铂加用榄香烯治疗。比较两组患者的临床疗效,治疗前后的细胞角蛋白19片段抗原21-1(CYFRA21-1)和神经元特异性烯醇化酶(NSE)、T淋巴细胞亚群及炎症因子水平。【结果】 观察组疾病控制率为80.30%,高于对照组的47.76%(P<0.05);治疗后,观察组患者的CYFRA21-1、NSE、CD8⁺和炎症因子水平低于对照组(P<0.05),CD3⁺、CD4⁺、CD4⁺/CD8⁺高于对照组(P<0.05)。【结论】 榄香烯联合洛铂治疗肺癌性胸腔积液,可有效降低患者的CYFRA21-1、NSE水平,调节炎症因子和T淋巴细胞亚群水平,提高临床疗效。

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	谷国梅

关键词 ：肺肿瘤, 胸腔积液, 恶性, 榄香烯, 铂化合物

Abstract：【Objective】 To investigate the clinical efficacy of elemene combined with lobaplatin in patients with malignant pleural effusion caused by lung cancer. 【Methods】 A total of 133 patients with lung cancer–related malignant pleural effusion were randomly divided into an observation group(n=66) and a control group(n=67). The control group received lobaplatin in addition to conventional treatment, while the observation group received lobaplatin combined with elemene. Clinical efficacy, as well as levels of cytokeratin 19 fragment antigen 21-1(CYFRA21-1), neuron-specific enolase(NSE), T-lymphocyte subsets, and inflammatory factors before and after treatment were compared between the two groups. 【Results】 The disease control rate in the observation group was 80.30%, which was significantly higher than 47.76% in the control group(P<0.05). After treatment, CYFRA21-1, NSE, CD8⁺, and inflammatory factor levels in the observation group were lower than those in the control group(P<0.05), while CD3⁺, CD4⁺, and CD4⁺/CD8⁺ levels in the observation group were higher than those in the control group(P<0.05). 【Conclusion】 Elemene combined with lobaplatin can effectively reduce CYFRA21-1 and NSE levels, modulate inflammatory factors and T-lymphocyte subsets, and improve clinical efficacy in patients with lung cancer-associated malignant pleural effusion.

Key words： Lung Neoplasms Pleural Effusion, Malignant Elemene Platinum Compounds

收稿日期: 2024-12-12

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R734.2

引用本文:

谷国梅. 榄香烯联合洛铂治疗肺癌性胸腔积液患者的疗效[J]. 医学临床研究, 2026, 43(1): 72-74.
GU Guomei. Efficacy of Elemene Combined with Lobaplatin in the Treatment of Malignant Pleural Effusion of Lung Cancer Patients. JOURNAL OF CLINICAL RESEARCH, 2026, 43(1): 72-74.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.01.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I1/72

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