Abstract：【Objective】 To explore the impact of olanzapine combined with cognitive behavioral therapy(CBT) on the quality of life and clinical efficacy in patients with schizophrenia.【Methods】 A total of 106 patients with schizophrenia admitted to our hospital from January 2023 to January 2025 were selected. According to different treatment methods, they were divided into the observation group(olanzapine combined with CBT) and the control group(olanzapine alone), with 53 cases in each group. Both groups received treatment for 12 weeks. The personality traits and psychological status [Minnesota Multiphasic Personality Inventory(MMPI) scores], rehabilitation efficacy [Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS) scores], quality of life [World Health Organization Quality of Life-Brief Version(WHOQOL-BREF) scores], and symptom improvement [Positive and Negative Syndrome Scale(PANSS) scores] were compared between the two groups before and after treatment.【Results】 After treatment, the scores of negative symptoms, general symptoms, and positive symptoms in both groups were lower than those before treatment; the scores of negative symptoms and general symptoms in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the scores of work therapy, life ability, social ability, care and interest, and hygiene ability in both groups were lower than those before treatment; the scores in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the MMPI scores of both groups were lower than those before treatment; the score in the observation group was lower than that in the control group, with a statistically significant difference(P<0.05). After treatment, the scores of physical health, social relations, environmental dimension, and mental health in both groups were higher than those before treatment; the scores in the observation group were higher than those in the control group, with statistically significant differences(P<0.05).【Conclusion】 Olanzapine combined with CBT has a significant effect on relieving negative symptoms and general symptoms of schizophrenia patients, achieves good rehabilitation efficacy, can improve patients' personality traits and psychological status, and enhance their quality of life.
徐孝荣, 张娇娇, 夏婷婷. 奥氮平联合认知行为治疗对精神分裂症患者生活质量及临床疗效的影响[J]. 医学临床研究, 2025, 42(9): 1565-1568.
XU Xiaorong, ZHANG Jiaojiao, XIA Tingting. The Impact of Olanzapine Combined with Cognitive Behavioral Therapy on Quality of Life and Clinical Efficacy in Patients with Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1565-1568.
2025, Vol. 42 
