Efficacy of Different Doses of Olanzapine in Treating Elderly Patients with Depressive Disorders Accompanied by Anxiety and Pain
TAO Tao, ZHANG Boyu, ZHENG Shuang, et al
Department of Anxiety and Depression, Affiliated Psychological Hospital of Anhui Medical University/Anhui Provincial Mental Health Center/Hefei Fourth People's Hospital, Hefei Anhui 230000
Abstract：【Objective】To investigate the efficacy of different doses of olanzapine in treating elderly depression patients with comorbid anxiety and pain, as well as its effects on somatic symptoms and sleep quality. 【Methods】 A total of 120 elderly patients with depression plus comorbid anxiety and pain from our hospital were randomly divided into a low-dose group and a high-dose group, with 60 patients in each group. Both groups were treated with paroxetine, while patients in the control group received a high dose of olanzapine(10 mg/dose) and in the observation group received a low dose of olanzapine(2.5 mg/dose), both for three months. The effectiveness and adverse reactions of the two groups were compared. The scores on the Hamilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA), Patient Health Questionnaire-15(PHQ-15) for the severity of somatic symptoms, Pittsburgh Sleep Quality Index(PSQI), and levels of fasting blood glucose(FBG), total cholesterol(TC) and triglycerides(TG) were compared before and after treatment in both groups.【Results】 There was no significant statistical difference in the overall effectiveness rate between the two groups(P>0.05). There were no significant statistical differences in the HAMD, HAMA, and PHQ-15 scores between the two groups either before or after treatment(P>0.05), while there was a significant reduction in the scores after treatment if compared to before treatment in each group(P<0.05). There were no significant statistical differences in the individual and total PSQI scores between the two groups before and after treatment(P>0.05), however, the scores of both groups after treatment were significantly lower than those before treatment(P<0.05). There were no significant statistical differences in levels of FBG, TC and TG between the two groups before treatment(P>0.05). After treatment, the FBG, TC, and TG levels in the high-dose group were significantly higher than those before treatment, while the FBG,TC and TG levels of the high-dose group were significantly higher than those of the low-dose group(P<0.05). The total incidence of adverse reactions in the low-dose group was significantly lower than that in the high-dose group(P<0.05).【Conclusion】 Olanzapine can improve depression, anxiety, somatic symptoms, and sleep quality in elderly patients with depressive disorder plus comorbid anxiety and pain. Using a low dose of olanzapine can reduce the risk of hyperglycemia and hyperlipidemia, and it has fewer adverse reactions.
陶涛, 张博宇, 郑爽, 张许来. 不同剂量奥氮平治疗老年抑郁障碍伴焦虑痛苦患者的疗效*[J]. 医学临床研究, 2024, 41(3): 336-339.
TAO Tao, ZHANG Boyu, ZHENG Shuang, et al. Efficacy of Different Doses of Olanzapine in Treating Elderly Patients with Depressive Disorders Accompanied by Anxiety and Pain. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 336-339.
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2024, Vol. 41 
