Abstract：【Objective】To explore the efficacy of different dosages of escitalopram in the treatment of patients with generalized anxiety disorder (GAD) and its effect on plasma levels of 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA).【Methods】A total of 86 patients with GAD admitted to our hospital were divided into the low,medium,and high dosage groups according to the different dosages of the treatment drug escitalopram,with initial dosages of 5 mg/d (low),10 mg/d (medium),and 20 mg/ d (high),respectively. The efficacy,Hamilton Anxiety Scale (HAMA) scores,Clinical Global Impression-Severity Scale (CGI-SI) scores,plasma levels of 5-HT and GABA,and the incidence of adverse reactions were compared among the three groups.【Results】The total effective rates in the medium-dosage group and high-dosage group were 93.10% (27/29) and 96.30% (26/27),respectively,which were significantly higher than 73.33% (22/30) in the low-dosage group (all P<0.05). There was no statistically significant difference in the total effective rate between the medium-dosage group and high-dosage group (P>0.05). HAMA and CGI-SI scores of the three groups after treatment were lower than those before treatment (P<0.05). The HAMA scores of the medium-dosage group and high-dosage group were significantly lower than that of the low-dosage group after treatment (P<0.05),but there was no statistically significant difference between the medium-dosage group and high-dosage group (P>0.05). The plasma levels of 5-HT and GABA in the three groups after treatment were higher than those before treatment (P<0.05). The plasma levels of 5-HT and GABA in the medium-dosage group and high-dosage group were significantly higher than those in the low-dosage group after treatment (P<0.05),but there was no statistically significant difference between the medium-dosage group and high-dosage group (P>0.05). The incidence of adverse reactions in the low-dosage group and medium-dosage group was 10.00% (3/30) and 17.24% (3/29),which were significantly lower than the 44.44% (12/27) in the high-dosage group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the low-dosage group and medium-dosage group (P>0.05).【Conclusion】Compared with low-dosage escitalopram treatment for patients with GAD,medium and high dosages can achieve better efficacy through effectively alleviating patients' clinical symptoms. And the medium-dosage group has a lower incidence of adverse reactions than the high-dosage group,with higher safety.
曹静, 李娟. 不同剂量艾司西酞普兰治疗广泛性焦虑患者的疗效及对5-HT、GABA含量的影响[J]. 医学临床研究, 2023, 40(9): 1303-1306.
CAO Jing, LI Juan. Efficacy of Different Dosages of Escitalopram in the Treatment of Generalized Anxiety Disorder Patients and its Impact on 5-HT and GABA Levels. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1303-1306.
2023, Vol. 40 
