Abstract：【Objective】To investigate the effect of low dose ketamine on postoperative pain in patients undergoing laparoscopic appendectomy (LA). 【Methods】Sixty patients with acute appendicitis treated with LA were randomly divided into two groups, 30 in each group. In the group K, 10ml ketamine (0.3mg / kg) was given intravenously 10 minutes before suturing, while in the group C, normal saline (10ml) was given. The pain, sedation, inflammatory factors and adverse reactions were compared between the two groups. 【Results】The visual analogue score (VAS) of 30 minutes (T0), 6 hours (T1), 12 hours (T2), 24 hours (T3) and 48 hours (T4) after extubation in Group K was significantly lower than that in group C (P<0.05).The Ramsay Sedation scores of T1 and T2 in the group K were significantly higher than those of the group C (P<0.05); the serum C-reactive protein (CRP) levels of T1, T2 and T3 were significantly lower than those of the group C (P<0.05); the total incidence of adverse reactions in the group K was 6.67% (2 / 30), significantly lower than that of the group C 20.00% (6 /30) (P<0.05). 【Conclusion】Low dose ketamine can relieve the pain of La patients before suturing. The effect of sedation is good, the level of serum CRP is stable, and the incidence of adverse reactions is reduced.
2019, Vol. 36 
