信迪利单抗联合SOX方案治疗进展期胃癌的疗效

doi:10.3969/j.issn.1671-7171.2026.06.020

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摘要 【目的】探讨信迪利单抗联合SOX方案治疗进展期胃癌的临床疗效。【方法】选择2021年6月至2025年6月本院收治的90例进展期胃癌患者,随机分为对照组(采用SOX方案治疗)和观察组(采用信迪利单抗联合SOX方案治疗),每组45例。比较两组治疗前后的免疫功能指标、血管新生指标[内皮细胞抑制素(ES)、血管内皮生长因子(VEGF)、血管生成素2(Ang-2)]、肿瘤标志物[糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)]、功能状态[卡氏功能状态(KPS)评分]、日常生活能力[日常生活能力评定量表(ADL)评分]、不良反应发生情况。【结果】治疗4个疗程后,观察组CD3⁺、CD4⁺、CD4⁺/CD8⁺水平高于对照组,CD8⁺水平低于对照组(均P<0.05)。观察组ES水平高于对照组,VEGF与Ang-2水平低于对照组(P<0.05)。观察组CA125、CA199、CEA水平低于对照组(P<0.05),KPS评分和ADL评分高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】信迪利单抗联合 SOX 方案治疗进展期胃癌,可有效增强患者免疫功能,抑制肿瘤血管生成,降低肿瘤标志物水平,提高生活质量,且安全性较好。

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	马子涵
	高展
	乔艳静

关键词 ：胃肿瘤, 抗体,单克隆, 抗肿瘤联合化疗方案, 治疗结果

Abstract：【Objective】 To investigate the clinical efficacy of sintilimab combined with the SOX regimen in the treatment of advanced gastric cancer. 【Methods】 A total of 90 patients with advanced gastric cancer admitted to our hospital between June 2021 and June 2025 were randomly divided into a control group (treated with the SOX regimen) and an observation group (treated with sintilimab combined with the SOX regimen), with 45 patients in each group. Immune function indicators, angiogenesis indicators [endostatin (ES), vascular endothelial growth factor (VEGF), and angiopoietin-2 (Ang-2)], tumor markers [carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA)], functional status [Karnofsky Performance Status (KPS) score], activities of daily living [Activities of Daily Living (ADL) score], and adverse reactions were compared between the two groups before and after treatment. 【Results】 After 4 cycles of treatment, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ in the observation group were significantly higher than those in the control group, while the CD8⁺ level was significantly lower than that in the control group (all P<0.05). The ES level of posttreatment in the observation group was significantly higher than that in the control group, whereas VEGF and Ang-2 levels were significantly lower than those in the control group (P<0.05). Levels of CA125, CA19-9, and CEA in the observation group were significantly lower than those in the control group (P<0.05), while KPS and ADL scores were significantly higher than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Sintilimab combined with the SOX regimen for advanced gastric cancer can effectively enhance immune function, inhibit tumor angiogenesis, reduce tumor marker levels, and improve quality of life, with good safety.

Key words： Stomach Neoplasms Antibodies, Monoclonal Antineoplastic Combined Chemotherapy Protocols Treatment Outcome

收稿日期: 2025-07-18

中图分类号:

R735.2

引用本文:

马子涵, 高展, 乔艳静. 信迪利单抗联合SOX方案治疗进展期胃癌的疗效[J]. 医学临床研究, 2026, 43(6): 951-954.
MA Zihan, GAO Zhan, QIAO Yanjing. Efficacy of Sintilimab Combined with the SOX Regimen in the Treatment of Advanced Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2026, 43(6): 951-954.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.06.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I6/951

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