血清肿瘤标志物联合窄带成像-放大内镜在早期消化道肿瘤良恶性鉴别中的应用价值

doi:10.3969/j.issn.1671-7171.2026.04.010

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摘要 【目的】探讨血清肿瘤标志物联合窄带成像-放大内镜(NBI-ME)鉴别早期消化道肿瘤良恶性的价值。【方法】接受内镜检查治疗的216例患者,术后病理检查结果为消化道恶性肿瘤的104例患者为观察组,112例良性病变患者为对照组。比较两组患者的一般资料、肿瘤标志物[癌胚抗原(CEA)、肿瘤特异性生长因子(TSGF)、糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)]、NBI-ME检查的特征;比较普通白光内镜和NBI-ME两种成像技术诊断病灶的特异性及准确性;采用受试者工作特征(ROC)曲线对相关指标诊断效能进行评估。【结果】观察组患者CEA、TSGF、CA19-9、AFP水平均高于对照组(P<0.05);观察组患者中肿瘤组织出现不连续边界线、不规则表面微结构和微血管不规则的比例高于对照组(P<0.05)。NBI-ME图像评分高于普通白光内镜(P<0.05)。ROC曲线结果显示,血清肿瘤标志物联合NBI-ME的诊断效能最高,准确度、灵敏度和特异度分别为94.44%、95.19%和93.75%。【结论】血清肿瘤标志物联合NBI-ME在消化道早期肿瘤患者中阳性检出率较高,值得临床推广。

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	宋艳华
	王建锋

关键词 ：消化系统肿瘤, 生物标记, 肿瘤, 内窥镜检查, 诊断, 鉴别

Abstract：【Objective】 To investigate the value of serum tumor markers combined with narrow-band imaging-magnifying endoscopy (NBI-ME) in differentiating benign and malignant early gastrointestinal tumors. 【Methods】 A total of 216 patients who underwent endoscopic examination and treatment were enrolled. According to postoperative pathological results, 104 patients with malignant gastrointestinal tumors were assigned to the observation group, and 112 patients with benign lesions were assigned to the control group. General clinical data, serum tumor markers [carcinoembryonic antigen (CEA), tumor-specific growth factor (TSGF), carbohydrate antigen 19-9 (CA19-9), and alpha-fetoprotein (AFP)], and NBI-ME features were compared between the two groups. The lesion characteristics and diagnostic accuracy obtained by conventional white-light endoscopy and NBI-ME were compared. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the relevant indicators. 【Results】 Serum levels of CEA, TSGF, CA19-9, and AFP in the observation group were significantly higher than those in the control group. The proportions of discontinuous lesion borders, irregular surface microstructures, and irregular microvascular patterns in tumor tissues were significantly higher in the observation group than in the control group (P<0.05). The NBI-ME image scores were significantly higher than those of conventional white-light endoscopy (P<0.05). ROC analysis showed that the combination of serum tumor markers and NBI-ME had the highest diagnostic efficacy, with the accuracy, sensitivity, and specificity of 94.44%, 95.19%, and 93.75%, respectively. 【Conclusion】 The combined use of serum tumor markers and NBI-ME demonstrates a high positive detection rate in patients with early gastrointestinal tumors and it is worthy of clinical application.

Key words： Digestive System Neoplasms Biomarkers, Tumor Endoscopy Diagnosis, Differential

收稿日期: 2025-12-01

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R735

引用本文:

宋艳华, 王建锋. 血清肿瘤标志物联合窄带成像-放大内镜在早期消化道肿瘤良恶性鉴别中的应用价值[J]. 医学临床研究, 2026, 43(4): 563-565.
SONG Yanhua, WANG Jianfeng. Application of Serum Tumor Markers Combined with Narrow-Band Imaging-Magnifying Endoscopy in the Differential Diagnosis of Benign and Malignant Early Gastrointestinal Tumors. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 563-565.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.04.010 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I4/563

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