Application of Dexmedetomidine Pretreatment Combined with Low-Dose Propofol in Aortic Dissection Interventional Surgery
XU Binga, DONG Xiaolongb, ZHANG Xujic
Jiaozuo People's Hospital: a. Anesthesia and Surgery Center; b. Department of Cardiac and Great Vascular Surgery; c. Interventional Department, Jiaozuo Henan 454000
Abstract：【Objective】 To investigate the clinical effects of dexmedetomidine(Dex) pretreatment combined with low-dose propofol in patients undergoing aortic dissection(AD) interventional surgery.【Methods】 Eighty-four patients scheduled for AD interventional surgery were randomly assigned to an observation group or a control group, with 42 cases in each group. The control group received conventional full-dose propofol induction and maintenance, while the observation group received Dex pretreatment before anesthesia induction combined with low-dose propofol induction. Hemodynamic parameters[mean arterial pressure(MAP) and heart rate(HR)]were compared between the two groups before induction, at 1 minute after intubation, 30 minutes after the start of surgery, and at the end of surgery. Additional comparisons included operation time, propofol dosage, awakening time, mechanical ventilation duration, sedation and analgesia outcomes before surgery and 2 hours postoperatively [Ramsay sedation score and visual analogue scale(VAS)], as well as safety indicators.【Results】 At 1 minute after intubation, 30 minutes after surgery initiation, and at the end of surgery, the observation group had significantly higher MAP and lower HR compared with the control group(P<0.05). There was no significant difference in operation time between the two groups(P>0.05). The observation group required less propofol and had shorter awakening and mechanical ventilation times than the control group(P<0.05). Two hours postoperatively, the observation group had higher Ramsay scores and lower VAS scores(P<0.05) compared to the control group. The incidence of adverse events showed no statistically significant difference between the two groups(P>0.05).【Conclusion】 Dex pretreatment combined with low-dose propofol can effectively maintain hemodynamic stability in patients undergoing AD interventional surgery, reduce propofol requirements, promote rapid postoperative awakening, shorten mechanical ventilation time, improve postoperative sedation and analgesia quality, and demonstrates good safety.
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2026, Vol. 43 
