Abstract:【Objective】 To explore the risk factors and nursing interventions for supine hypotensive syndrome(SHS) during cesarean section.【Methods】 A total of 80 parturients who underwent cesarean section in our hospital from January 2023 to January 2025 were selected as the research subjects. They were divided into the non-SHS group(n=59) and the SHS group(n=21) according to whether SHS occurred during the operation. Univariate analysis and Logistic multivariate regression analysis were used to identify the risk factors for SHS in parturients during cesarean section.【Results】 Among the 80 parturients undergoing cesarean section, 21 cases developed SHS. Univariate analysis showed that age, fear of childbirth, surgical position, and oxygenation index(OI) were influencing factors for SHS in parturients during cesarean section(P<0.05). Logistic multivariate regression analysis revealed that elderly parturients, supine surgical position, fear of childbirth, and low OI were independent risk factors for SHS in parturients during cesarean section(P<0.05).【Conclusion】 There are multiple influencing factors for SHS in parturients during cesarean section. Among them, elderly parturients, supine surgical position, fear of childbirth, and low OI are independent risk factors. Nurses should strengthen the monitoring of parturients' vital signs, assist parturients in adopting the left lateral position during surgery, alleviate their fear of childbirth, and maintain normal OI of the body, so as to effectively prevent SHS during cesarean section.