润肺通络汤联合阿奇霉素在阴虚肺热型支原体肺炎持续性咳嗽患儿中的应用效果

doi:10.3969/j.issn.1671-7171.2025.07.021

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摘要【目的】探讨润肺通络汤联合阿奇霉素在阴虚肺热型支原体肺炎持续性咳嗽患儿中的应用效果。【方法】选择2021年10月至2024年6月本院收治的92例阴虚肺热型支原体肺炎持续性咳嗽患儿,根据随机数字表法将患儿分为对照组和观察组,每组46例。对照组采用阿奇霉素治疗,观察组在对照组基础上联合润肺通络汤治疗,连续治疗3周。比较两组中医证候评分、临床疗效、不良反应发生率,咳嗽、肺部湿啰音消失时间,血清白三烯、超敏C反应蛋白(hs-CRP)水平。【结果】治疗后,两组主证评分、次证评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗后肺部湿啰音、咳嗽消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血清白三烯、hs-CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组、对照组不良反应总发生率比较,差异无统计学意义(P=0.503)。【结论】润肺通络汤联合阿奇霉素治疗阴虚肺热型支原体肺炎持续性咳嗽患儿临床疗效较好,可减轻炎症反应,且安全性良好。

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	史永辉
	高士敬

关键词 ：肺炎,支原体, 咳嗽, 叠氮红霉素, 儿童, 治疗结果

Abstract：【Objective】To explore the application effect of Runfei Tongluo Decoction combined with azithromycin in children with persistent cough due to mycoplasma pneumonia of Yinxu Feire type. 【Methods】A total of 92 children with persistent cough due to mycoplasma pneumonia admitted to our hospital from October 2021 to June 2024 were selected and divided into the control group and the observation group according to the random number table method, with 46 cases in each group. The control group was treated with azithromycin, and the observation group was treated with Runfei Tongluo Decoction on the basis of the control group, with continuous treatment for 3 weeks. The TCM syndrome scores, clinical efficacy, incidence of adverse reactions, disappearance time of cough and lung rales, and serum levels of leukotriene and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups. 【Results】After treatment, the scores of primary and secondary syndromes in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). After treatment, the disappearance time of lung rales, cough and hospital stay in the observation group were shorter than those in the control group, with statistically significant differences (P<0.05). The total clinical effective rate of the observation group was higher than that of the control group, with a statistically significant difference (P<0.05). After treatment, the serum levels of leukotriene and hs-CRP in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P=0.503).【Conclusion】 Runfei Tongluo Decoction combined with azithromycin has a good clinical effect in the treatment of children with persistent cough due to mycoplasma pneumonia of Yinxu Feire type, which can reduce inflammatory response with good safety.

Key words： Pneumonia, Mycoplasma Cough Azithromycin Child Treatment Outcome

收稿日期: 2025-03-20

中图分类号:

R725.631

引用本文:

史永辉, 高士敬. 润肺通络汤联合阿奇霉素在阴虚肺热型支原体肺炎持续性咳嗽患儿中的应用效果[J]. 医学临床研究, 2025, 42(7): 1178-1180.
SHI Yonghui, GAO Shijing. Application Effect of Runfei Tongluo Decoction Combined with Azithromycin in Children with Persistent Cough Due to Mycoplasma Pneumonia of Yinxu Feire Type. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1178-1180.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1178

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