不同栓塞材料用于巨大肝血管瘤介入栓塞术中对患者瘤体体积及术后并发症发生情况的影响

doi:10.3969/j.issn.1671-7171.2025.06.021

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摘要【目的】探讨不同栓塞材料用于巨大肝血管瘤介入栓塞术中对患者瘤体体积及术后并发症发生情况的影响。【方法】回顾性分析2020年1月至2022年1月本院收治的94例巨大肝血管瘤患者的临床资料,根据术中栓塞材料的不同将患者分为平阳霉素组和博来霉素组,每组47例。随访6个月,比较两组患者临床疗效、血供分型、术中碘化油用量、住院情况,以及血清甲胎蛋白(AFP)、肿瘤特异性生长因子(TSGF)、肿瘤坏死因子-α(TNF-α)水平,记录两组术后并发症发生情况。【结果】两组血供分型、术中碘化油用量、住院时间、住院费用比较,差异均无统计学意义(P>0.05)。平阳霉素组总有效率高于博来霉素组,差异有统计学意义(P<0.05)。术后3个月及术后6个月,平阳霉素组瘤体直径均小于博来霉素组,瘤体缩小率均高于博来霉素组,差异有统计学意义(P<0.05)。术后6个月,两组血清AFP、TSGF、TNF-α水平均低于术前,且平阳霉素组低于博来霉素组,差异有统计学意义(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。【结论】巨大肝血管瘤介入栓塞术中应用平阳霉素和碘油混合液有利于提高临床疗效,且无严重并发症,安全性较高。

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	叶成

关键词 ：血管瘤, 肝肿瘤, 栓塞, 治疗性, 手术后并发症

Abstract：【Objective】 To investigate the influence of different embolic materials on tumor volume and postoperative complications in interventional embolization of giant hepatic hemangioma. 【Methods】Clinical data of 94 patients with giant hepatic hemangioma admitted to our hospital from January 2020 to January 2022 were retrospectively analyzed. Patients were divided into the pingyangmycin group and the bleomycin group according to the embolic materials used during surgery, with 47 cases in each group. After 6 months of follow-up, clinical efficacy, blood supply typing, intraoperative lipiodol dosage, hospitalization status, and serum levels of alpha-fetoprotein (AFP), tumor-specific growth factor (TSGF), and tumor necrosis factor-α (TNF-α) were compared between the two groups. Postoperative complications were recorded. 【Results】There were no significant differences in blood supply typing, intraoperative lipiodol dosage, hospitalization time, or hospitalization costs between the two groups (P>0.05). The total effective rate of the pingyangmycin group was higher than that of the bleomycin group (P<0.05). At 3 and 6 months postoperatively, the tumor diameter in the pingyangmycin group was smaller, and the tumor shrinkage rate was higher than those in the bleomycin group (P<0.05). At 6 months postoperatively, serum levels of AFP, TSGF, and TNF-α in both groups were lower than those before surgery, and the levels in the pingyangmycin group were lower than those in the bleomycin group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). 【Conclusion】 The application of pingyangmycin-lipiodol mixture in interventional embolization of giant hepatic hemangioma is beneficial to improving clinical efficacy, with no serious complications and high safety.

Key words： Hemangioma Liver Neoplasms Embolization, Therapeutic Postoperative Complications

收稿日期: 2024-05-20

中图分类号:

R735.7

引用本文:

叶成. 不同栓塞材料用于巨大肝血管瘤介入栓塞术中对患者瘤体体积及术后并发症发生情况的影响[J]. 医学临床研究, 2025, 42(6): 985-988.
YE Cheng. Influence of Different Embolic Materials on Tumor Volume and Postoperative Complications in Interventional Embolization of Giant Hepatic Hemangioma. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 985-988.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.06.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I6/985

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