Abstract：【Objective】To investigate the effect of traditional Chinese medicine fumigation on alleviating joint symptoms of rheumatoid arthritis (RA) patients and its impact on cytokines.【Methods】A total of 114 RA patients were randomly divided into two groups. Patients in the control group received methotrexate tablet treatment, while patients in the observation group received additional traditional Chinese medicine fumigation therapy. The changes in joint symptoms, Disease Activity Score of 28 joints (DAS28), erythrocyte sedimentation rate (ESR), cyclic citrullinated peptide antibodies (CCP-AB), C-reactive protein (CRP), rheumatoid factor (RF), α1-acid glycoprotein (α1-AGP), interleukin-35 (IL-35), and interleukin-17(IL-17) levels before and after treatment in both groups were compared. 【Results】There were no significant differences in any of the indices between the two groups before treatment (P>0.05). After treatment, the scores of joint symptoms and DAS28 in both groups significantly decreased compared to before treatment (P<0.05). These scores in the observation group were lower than those in the control group (P<0.05). Post-treatment, IL-35 levels in both groups significantly increased (P<0.05), while level of IL-35 in the observation group was higher than that in the control group (P<0.05).CCP-AB, ESR, CRP, RF, α1-AGP, and IL-17 levels significantly decreased after treatment in both groups, and levels of ESR and CCP-AB were significantly lower in the observation group compared to the control group (P<0.05). 【Conclusion】TCM fumigation can reduce the expression of ESR, CRP, and RF in RA patients through improving symptoms such as joint pain, swelling, tenderness, and functional impairment.
闫家玲. 中药熏蒸治疗类风湿性关节炎的疗效及对细胞因子的影响[J]. 医学临床研究, 2023, 40(12): 1899-1901.
YAN Jialing. Efficacy of Traditional Chinese Medicine Fumigation in Treating Rheumatoid Arthritis and its Impact on Cytokines. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1899-1901.
[1] 严林.炎症因子对类风湿性关节炎患者骨代谢及脂代谢的影响[J].医学临床研究,2018,35(4):716-718.
[2] BOUMIA V K,KITAS G,PROTOGEROU A D,et al.Impact of non steroidal anti inflammatory drugs on cardiovascular risk:is it the same in osteoarthritis and rheumatoid arthritis?[J].Mod Rheumatol,2017,27(4):559-569.
[3] 叶霖,王友莲.类风湿性关节炎的中西医发病机制综述[J].江西医药,2017,52(1):88-91.
[4] 郑慧芳,徐丽萍,戴巧定,等.中药熏蒸治疗活动期类风湿关节炎的疗效观察及护理[J].中华现代护理杂志,2016,22(26):3763-3765.
[5] 中华医学会风湿病学分会.类风湿关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(4):265-270.
[6] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:47.
[7] SMOLEN J S,ALETAHA D,Mcinnes I B.Rheumatoid arthritis[J].Lancet,2016,388(10055): 2023-2038.
[8] 李培培,邰宇,黄传兵,等.美洛昔康片联合甲氨蝶呤片治疗类风湿关节炎的临床研究[J].中国临床药理学杂志,2016,32(22):2023-2026.
[9] 康正,程春生.热通汤熏洗治疗寒湿痹阻型类风湿性关节炎临床观察[J].陕西中医,2016,37(11):1488-1489.
[10] 娄爱菊,吴炜戎,蔡晓燕,等.氧化应激和骨代谢水平与类风湿关节炎合并低骨量的相互关系[J].中国骨质疏松杂志,2016,22(3):335-339.
[11] 李建,荣兵,贾峻,等.蠲痹汤加减对风寒湿痹型类风湿关节炎患者关节液中炎症因子,血清MMP-3、OPG及RANKL的影响[J].中国实验方剂学杂志,2017,23(22):165-170.
[12] 李茜,张国栋,刘毅,等.IL-17和IRF4在类风湿关节炎中的表达及临床意义[J].西部医学,2016,28(11):1506-1509.
2023, Vol. 40 
