经颅直流电刺激联合石杉碱甲治疗老年血管性痴呆患者的临床疗效

doi:10.3969/j.issn.1671-7171.2023.09.026

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摘要【目的】探讨经颅直流电刺激(tDCS)联合石杉碱甲治疗老年血管性痴呆(VD)患者的临床疗效。【方法】选取2021年3月至2022年3月本院收治的100老年VD患者,根据随机数字表法将其分成观察组和对照组,每组50例。比较两组总有效率、治疗前后简易智能精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分,P300电位N2、N3潜伏期及P3波幅,大脑前动脉(ACA)、大脑后动脉(PCA)、大脑中动脉(MCA)血流速度,血清5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平。【结果】观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗3个月后,两组MoCA、MMSE评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组P300电位N2、N3潜伏期较治疗前缩短,P3波幅较治疗前升高,观察组P300电位N2、N3潜伏期较对照组短,P3波幅较对照组高(P<0.05);两组ACA、MCA、PCA脑血流速度高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组血清5-HT、DA、NE水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。【结论】tDCS联合石杉碱甲治疗老年VD患者可进一步提升疗效,改善患者精神状态及认知功能,改善脑血流灌注及神经电生理调节效应,且可调节神经因子水平。

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	梁姗姗

关键词 ：痴呆,血管性/治疗, 电刺激疗法, 倍半萜类/治疗应用, 治疗结果

Abstract：【Objective】To investigate the effect of transcranial direct current stimulation (tDCS) combined with huperzine A in the treatment of senile vascular dementia (VD).【Methods】A total of 100 elderly patients with VD in our hospital from March 2021 to March 2022 were selected and divided into the observation group (n=50) and the control group (n=50) according to the random number table method. Patients in the control group B received tDCS therapy,while patients in the observation group received tDCS combined with huperzine A therapy. The total effective rate,Mini-Mental State Examination (MMSE),Montreal Cognitive Assessment (MoCA) score,P300 potential N2,N3 latency and P3 amplitude,anterior cerebral artery (ACA),posterior cerebral Arterial (PCA),middle cerebral artery (MCA) blood flow velocity,serum serotonin (5-HT),dopamine (DA),and norepinephrine (NE) levels were compared between the two groups.【Results】The total effective rate of the observation group was higher than that of the control group (P<0.05). After 3 months of treatment,the MoCA and MMSE scores of the observation group were higher than those of the control group (P<0.05); And the observation group was higher than that of the control group,the difference was statistically significant (P<0.05). The N2 and N3 latency of P300 potential in the two groups were shorter than before treatment,and the P3 amplitude was higher than before treatment. After 3 months of treatment,the latencies of N2 and N3 of P300 potential in the observation group were shorter than those in the control group,while the amplitude of P3 was higher than that in the control group (P<0.05). The cerebral blood flow velocity of ACA,MCA,and PCA in the two groups was higher than before treatment,and the cerebral blood flow velocity of ACA,MCA,and PCA in the observation group was higher than that of the control group. The difference was statistically significant (P<0.05). The serum 5-HT,DA,and NE levels of the two groups were higher than before treatment. The levels of 5-HT,DA,and NE in the observation group was higher than those the control group,and the difference was statistically significant (P<0.05).【Conclusion】The tDCS combined with huperzine A in the treatment of elderly VD patients can further improve the curative effect,improve cognitive function and mental state,improve cerebral blood perfusion and facial nerve electrophysiological regulation effect,and regulate the level of nerve factors.

Key words： Dementia,Vascular/TH Electric Stimulation Therapy Sesquiterpenoids/TU Treatment Outcome

收稿日期: 2022-07-21

中图分类号:

R749.16

引用本文:

梁姗姗. 经颅直流电刺激联合石杉碱甲治疗老年血管性痴呆患者的临床疗效[J]. 医学临床研究, 2023, 40(9): 1375-1377.
LIANG Shanshan. Efficacy of Transcranial Direct Current Stimulation Combined with Huperzine A in the Treatment of Senile Vascular Dementia Patients. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1375-1377.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.09.026 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I9/1375

[1] 李秀玲,吴学琴,王雅格.活血健脑方对血管性痴呆患者中医证候积分、精神状态及行为能力的影响[J].四川中医,2019,37(9):140-143.
[2] 张薇,王英,尉娜.丁苯酞胶囊联合银杏达莫注射液治疗老年血管性痴呆的疗效及对认知功能、氧化应激的影响[J].中西医结合心脑血管病杂志,2020,18(3):515-518.
[3] 李硕,倪伟,田浩梅.“调心通督”针刺法联合经颅直流电刺激对血管性痴呆的临床观察[J].湖南中医药大学学报,2020,40(4):469-472.
[4] 吕心可,李大伟,宋天琦,等.石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察[J].北华大学学报(自然科学版),2021,22(1):62-64.
[5] 国家卫计委脑卒中防治工程委员会.中国血管性认知障碍诊疗指导规范(2016年)[J].全科医学临床与教育,2016,14(5):484-487.
[6] 刘亚林,郭医杰,孟文娟,等.肌电生物反馈疗法联合奥拉西坦对老年血管性痴呆患者外周血血红素氧化酶-1、可溶性凋亡因子水平及认知功能的影响[J].中国医师进修杂志,2022,45(6):559-563.
[7] WOOD J L,WEINTRAUB S,COVENTRY C,et al. Montreal Cognitive Assessment (MoCA) performance and domain-specific index scores in amnestic versus aphasic dementia[J].J Int Neuropsychol Soc,2020,26(9):927-931.
[8] 孟胜喜,付剑亮,霍清萍,等.血管性痴呆患者血同型半胱氨酸、超敏C反应蛋白、D-二聚体、碱性成纤维细胞生长因子和脑源性神经营养因子水平及其临床意义[J].广西医学,2020,42(2):134-137.
[9] ZLOKOVIC B V,GOTTESMAN R F,BERNSTEIN K E,et al. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart,Lung,and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop[J].Alzheimers Dement,2020,16(12):1714-1733.
[10] 许玉红.养血清脑颗粒联合艾地苯醌治疗血管性痴呆的临床研究[J].现代药物与临床,2020,35(10):2019-2022.
[11] 邢晓娟,王丹,郭俊林.高压氧联合石杉碱甲治疗血管性痴呆患者的疗效观察[J].中华航海医学与高气压医学杂志,2019,26(6):623-625.
[12] 武利娟,贾小飞. 吡拉西坦片联合丁苯酞软胶囊治疗对老年血管性痴呆患者血清神经递质水平及认知功能的影响[J].临床医学工程,2023,30(3):321-322.
[13] 沈莹,陈松,余鸽,等.逍遥丸与艾司西酞普兰治疗血管性痴呆伴发抑郁的疗效对比分析[J].中华中医药学刊,2019,37(2):396.