Abstract：【Objective】 To explore the application value of contrast-enhanced ultrasound in the diagnosis of unknown small thyroid nodules using initial fine needle aspiration cytology (FNAC). 【Methods】 A total of 86 patients (88 nodules) with unknown initial FNAC diagnosis of small thyroid nodules admitted to the Yan'an University Affiliated Hospital from February 2019 to February 2022 were selected for the study. All patients underwent contrast-enhanced ultrasound examination and secondary FNAC. The results of contrast-enhanced ultrasound examination and secondary FNAC diagnosis of benign and malignant thyroid nodules were recorded. Based on the pathological diagnosis results as the gold standard, the value of contrast-enhanced ultrasound examination and secondary FNAC diagnosis of unknown malignant thyroid nodules in the initial FNAC diagnosis was analyzed through consistency analysis. 【Results】Among the 88 nodules, pathological diagnosis showed a total of 46 malignant nodules and 42 benign nodules. The results of contrast-enhanced ultrasound examination showed 54 malignant nodules, 40 pathologically diagnosed malignant nodules, and 14 benign nodules; 18 benign nodules, 3 malignant nodules with pathological diagnosis, and 15 benign nodules; 16 nodules cannot be clearly diagnosed, 3 malignant nodules can be pathologically diagnosed, and 13 benign nodules can be diagnosed. The secondary FNAC diagnosis results showed 11 malignant nodules, 10 pathological diagnoses of malignant nodules, and 1 benign nodule; 18 benign nodules, 8 malignant nodules with pathological diagnosis, and 10 benign nodules; 59 nodules were not clearly diagnosed, 28 malignant nodules and 31 benign nodules were pathologically diagnosed. The consistency analysis results showed that the sensitivity, specificity, and accuracy of contrast-enhanced ultrasound in the diagnosis of unknown small thyroid nodule malignancy in the initial FNAC were 0.870, 0.667, and 0.773, respectively; The sensitivity, specificity, and accuracy of the second FNAC diagnosis for unknown small thyroid nodule malignancy in the first FNAC were 0.217, 0.976, and 0.580, respectively. 【Conclusion】 Contrast-enhanced ultrasound has a high diagnostic efficacy and clinical application value in the diagnosis of benign and malignant small thyroid nodules with unknown initial FNAC diagnosis.
贾红娥, 刘红梅. 超声造影检查在初次FNAC诊断不明微小甲状腺结节中的应用价值[J]. 医学临床研究, 2023, 40(7): 1014-1017.
JIA Hong-e, LIU Hong-mei. The Application Value of Contrast-Enhanced Ultrasound in the Diagnosis of Unknown Small Thyroid Nodules in Initial FNAC. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1014-1017.
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2023, Vol. 40 
