Abstract：【Objective】This study aimed to explore the diagnostic value of intestinal fatty acid-binding protein (IFABP) combined with neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) testing in pediatric strangulated intestinal obstruction. 【Methods】Ninety-six cases of intestinal obstruction in children admitted to two hospitals were enrolled as the observation group, and 84 healthy children undergoing medical examinations during the same period were selected as the control group. Serum levels of IFABP, NLR, and PCT were compared between the two groups. The occurrence of strangulated intestinal obstruction was recorded, and the clinical characteristics of children with strangulated intestinal obstruction were compared with those of children with simple intestinal obstruction. Logistic regression analysis was used to determine the factors influencing the occurrence of strangulated intestinal obstruction, and receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic value of serum IFABP combined with NLR and PCT levels in pediatric strangulated intestinal obstruction. 【Results】The serum levels of IFABP, NLR, and PCT in the observation group were significantly higher than those in the control group (P<0.05). The incidence of strangulated intestinal obstruction among the 96 cases of intestinal obstruction was 43.75% (42/96). Children with strangulated intestinal obstruction had a higher incidence of peritoneal irritation signs, history of abdominal surgery, and elevated serum levels of IFABP, NLR, and PCT compared to those with simple intestinal obstruction; And the differences were statistically significant (P<0.05). Logistic regression analysis showed that serum levels of IFABP, NLR, PCT, and history of abdominal surgery were independent risk factors for pediatric strangulated intestinal obstruction (P<0.05). ROC analysis indicated that the optimal cutoff points for serum IFABP, NLR, and PCT levels in diagnosing pediatric strangulated intestinal obstruction were 375.80 pg/mL, 3.82 ng/mL, and 0.34 ng/mL, respectively, with corresponding area under the curve (AUC) values of 0.818, 0.786, and 0.821. The combination of these markers yielded the highest specificity and AUC in diagnostic performance. 【Conclusion】Children with strangulated intestinal obstruction exhibit elevated serum levels of IFABP, NLR, and PCT, which can serve as sensitive indicators for diagnosing pediatric strangulated intestinal obstruction. Furthermore, their diagnostic value is enhanced when used in combination.
寇振宇, 次苗苗. 肠脂肪酸结合蛋白联合NLR、PCT检测对小儿绞窄性肠梗阻的诊断价值[J]. 医学临床研究, 2023, 40(7): 1002-1005.
KOU Zhen-yu, CI Miao-miao. Diagnostic Value of Intestinal Fatty Acid Binding Protein Combined with NLR and PCT in Diagnosis of Strangulated Intestinal Obstruction in Children. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1002-1005.
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2023, Vol. 40 
