[1] GAO Y,HUANG R,CHEN R M,et al. Ischemic postconditioning altered microRNAs in human valve replacement[J].J Surg Res,2016,200(1):28-35. [2] DANIELSON K M,SHAH R,YERI A,et al. Plasma circulating extracellular RNAs in left ventricular remodeling post-myocardial infarction[J].EBioMedicine,2018,32:172-181. [3] 魏丽萍.心肌梗死小鼠microRNAs表达及干预后心功能变化的研究[J].天津医药,2018,46(8):851-855. [4] WANG Z H,SUN X Y,LI C L,et al. miRNA-21 expression in the serum of elderly patients with acute myocardial infarction[J].Med Sci Monit,2017,23:5728-5734. [5] CHEN H W,DONG Y,HE X H,et al. Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction[J].Drug Des Devel Ther,2018,12:823-836. [6] 孔燕茹.心脏磁共振成像评估急性心肌梗死预后指标研究进展[J].心血管病学进展,2018,39(1):100-102. [7] NERMA R,AZRA D N,ALEN D,et al. Serum aldosterone as predictor of progression of coronary heart disease in patients without signs of heart failure after acute myocardial infarction[J].Med Arch,2018,72(6):406-409. [8] WESTMAN P C,LIPINSKI M J,LUGER D,et al. Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction[J].J Am Coll Cardiol,2016,67(17):2050-2060. [9] 蒋易,燕艳丽,白建文. 抗细胞趋化因子CCL21单克隆抗体处理对小鼠急性心肌梗死后左心室重构及心功能的影响[J].中国应用生理学杂志,2018,34(3):197-200. [10] DONG S. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction[J].J Biol Chem,2009,284(43):29514-29525. [11] SONG Y,ZHANG C,ZHANG J X,et al. Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction[J].Theranostics,2019,9(8):2346-2360. [12] TU Y F,WAN L,FAN Y H,et al. Ischemic postconditioning-mediated miRNA-21 protects against cardiac ischemia/reperfusion injury via PTEN/Akt pathway[J].PLoS One,2013,8(10):e75872. [13] LI S H,FAN Q, HE S L,et al.MicroRNA-21 negatively regulates Treg cells through a TGF-β1/Smad-independent pathway in patients with coronary heart disease[J].Cell Physiol Biochem,2015,37(3):866-878. [14] FABIANI I. Micro-RNA-21 (biomarker) and global longitudinal strain (functional marker) in detection of myocardial fibrotic burden in severe aortic valve stenosis:A pilot study[J].J Transl Med,2016,14:248. [15] THUM T,GROSS C,FIEDLER J,et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts[J].Nature,2008,456(7224):980-984. [16] ZHOU X L,XU H,LIU Z B,et al. miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting jagged1[J].J Cell Mol Med,2018,22(8):3816-3824. [17] YUAN J X,CHEN H T,GE D W, et al. Mir-21 promotes cardiac fibrosis after myocardial infarction via targeting smad7[J].Cell Physiol Biochem,2017,42(6):2207-2219. [18] GARCÍA R,NISTAL J F,MERINO D,et al. p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling[J].Biochim Biophys Acta,2015,1852(7):1520-1530. [19] SYED M,BALL J P,MATHIS K W,et al. MicroRNA-21 ablation exacerbates aldosterone-mediated cardiac injury,remodeling,and dysfunction[J].Am J Physiol Endocrinol Metab,2018,315(6):e1154-e1167. [20] WANG F,FANG Q,CHEN C,et al. Recombinant adeno-associated virus-mediated delivery of MicroRNA-21-3p lowers hypertension[J].Mol Ther Nucleic Acids,2018,11:354-366. [21] WATANABE K,NARUMI T,WATANABE T,et al. The association between microRNA-21 and hypertension-induced cardiac remodeling[J].PLoS One,2020,15(2):e0226053. [22] WANG Z H,SUN X Y,LI C L,et al. miRNA-21 expression in the serum of elderly patients with acute myocardial infarction[J].Med Sci Monit,2017,23:5728-5734. [23] GU H Y,LIU Z Y,LI Y Q,et al. Serum-derived extracellular vesicles protect against acute myocardial infarction by regulating miR-21/PDCD4 signaling pathway[J].Front Physiol,2018,9:348.