Abstract：【Objective】 To investigate the correlation between ciRs-126 and acute kidney injury(AKI) in patients with sepsis. 【Methods】 Eighty patients with sepsis admitted to our hospital were divided into two groups according to the degree of renal injury:AKI group (30 cases) and non-AKI group (50 cases). General information,disease score and ciRs-126 levels of the two groups were compared. 【Results】 There were no differences in age,sex,body mass index (BMI),underlying complications,smoking history and drinking history between the two groups (P>0.05). There were no differences in tumor necrosis factor-α (TNF-α),hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels between the two groups (P>0.05). Serum creatinine (Scr) and serum urea nitrogen (BUN) levels in the AKI group were higher than that in the non-AKI group,while the glomerular filtration rate (eGFR) level in the AKI group was lower than that in non-AKI group (P<0.05). The sequential organ failure score (SOFA) and acute physiological and chronic health score (APACHE Ⅱ) in the group with AKI were higher than those in the group without AKI (P<0.05). The level of ciRs-126 in the group with AKI was higher than that in the group without AKI (P<0.05). ROC analysis showed that Scr,eGFR,SOFA,APACHE Ⅱ and ciRs-126 could be used to predict occurrence of AKI after sepsis,and the areas under the curve were 0.725,0.800,0.687,0.751 and 0.785,respectively,(P<0.05). Multivariate Logistic regression analysis confirmed that Scr≥156.70 μmol/L,eGFR≤84.58 mL/min,SOFA≥13.24 scores,APACHE Ⅱ≥29.26 scores,ciRs-126≥3.76 were risk factors for AKI after sepsis(P<0.05).【Conclusion】 The increase of ciRs-126 level can predict the occurrence of AKI in patients with sepsis. It is necessary to strengthen the monitoring of this index.
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2023, Vol. 40 
