医学临床研究
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医学临床研究  2023, Vol. 40 Issue (4): 504-507    DOI: 10.3969/j.issn.1671-7171.2023.04.007
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循环ciRs-126水平与脓毒症患者急性肾损伤的相关性
戚恒, 高婧*
西安市长安医院急诊科,陕西 西安 710016
Relationship between ciRs-126 and Acute Kidney Injury in Patients with Sepsis
QI Heng, GAO Jing
Department of Emergency,Xi'an Chang'an Hospital,Xi'an Shaanxi 710016
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摘要 【目的】探讨循环ciRs-126水平与脓毒症患者急性肾损伤(AKI)的相关性。【方法】本院收治的80例脓毒症患者,根据肾功能损伤程度分为AKI组(30例)和未发生AKI组(50例),比较两组临床资料、病情评分及循环ciRs-126水平。【结果】两组年龄、性别、体重指数(BMI)、基础合并症、吸烟史、饮酒史比较,差异均无统计学意义(P>0.05);两组肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6 (IL-6)水平比较,差异无统计学意义(P>0.05);AKI组患者血肌酐(Scr)、血清尿素氮(BUN)水平均高于未发生AKI组,肾小球滤过率(eGFR)水平低于未发生AKI组(P<0.05);AKI组序贯器官功能衰竭评分(SOFA)、急性生理与慢性健康状况评分Ⅱ(APACHE Ⅱ)均高于未发生AKI组(P<0.05),循环ciRs-126水平高于未发生AKI组(P<0.05);经受试者工作特征(ROC)曲线分析证明,Scr、eGFR、SOFA、APACHE Ⅱ、循环ciRs-126均可用于脓毒症后发生AKI的预测,曲线下面积分别为0.725、0.800、0.687、0.751、0.785(均P<0.05);多因素Logistic回归分析结果显示,Scr≥156.70 μmol/L、eGFR≤84.58 mL/min、SOFA≥13.24分、APACHE Ⅱ≥29.26分、循环ciRs-126≥3.76是脓毒症后发生AKI的危险因素(P<0.05)。【结论】在脓毒症患者中循环ciRs-126水平升高可预测AKI的发生,应加强此项指标的监测。
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戚恒
高婧
关键词 脓毒症/并发症急性肾损伤/并发症微RNAs    
Abstract:【Objective】 To investigate the correlation between ciRs-126 and acute kidney injury(AKI) in patients with sepsis. 【Methods】 Eighty patients with sepsis admitted to our hospital were divided into two groups according to the degree of renal injury:AKI group (30 cases) and non-AKI group (50 cases). General information,disease score and ciRs-126 levels of the two groups were compared. 【Results】 There were no differences in age,sex,body mass index (BMI),underlying complications,smoking history and drinking history between the two groups (P>0.05). There were no differences in tumor necrosis factor-α (TNF-α),hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels between the two groups (P>0.05). Serum creatinine (Scr) and serum urea nitrogen (BUN) levels in the AKI group were higher than that in the non-AKI group,while the glomerular filtration rate (eGFR) level in the AKI group was lower than that in non-AKI group (P<0.05). The sequential organ failure score (SOFA) and acute physiological and chronic health score (APACHE Ⅱ) in the group with AKI were higher than those in the group without AKI (P<0.05). The level of ciRs-126 in the group with AKI was higher than that in the group without AKI (P<0.05). ROC analysis showed that Scr,eGFR,SOFA,APACHE Ⅱ and ciRs-126 could be used to predict occurrence of AKI after sepsis,and the areas under the curve were 0.725,0.800,0.687,0.751 and 0.785,respectively,(P<0.05). Multivariate Logistic regression analysis confirmed that Scr≥156.70 μmol/L,eGFR≤84.58 mL/min,SOFA≥13.24 scores,APACHE Ⅱ≥29.26 scores,ciRs-126≥3.76 were risk factors for AKI after sepsis(P<0.05).【Conclusion】 The increase of ciRs-126 level can predict the occurrence of AKI in patients with sepsis. It is necessary to strengthen the monitoring of this index.
Key wordsSepsis/CO    Acute Kidney Injury/CO    MicroRNAs
收稿日期: 2022-08-20     
中图分类号:  R631.1  
通讯作者: * E-mail:chenruhaidi527@126.com   
引用本文:   
戚恒, 高婧. 循环ciRs-126水平与脓毒症患者急性肾损伤的相关性[J]. 医学临床研究, 2023, 40(4): 504-507.
QI Heng, GAO Jing. Relationship between ciRs-126 and Acute Kidney Injury in Patients with Sepsis. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 504-507.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.04.007     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I4/504
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