妇科恶性肿瘤患者围术期并发深静脉血栓的危险因素分析

doi:10.3969/j.issn.1671-7171.2021.02.009

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摘要 【目的】 探讨妇科恶性肿瘤患者围术期并发深静脉血栓(DVT)的危险因素。【方法】 本研究选取2010年1月至 2019 年12月发表的妇科恶性肿瘤并发DVT的文献进行Meta分析,探讨妇科肿瘤患者围术期并发DVT的危险因素。【结果】 共纳入文献12篇,13项危险因素,包括年龄、体质量指数(BMI)、手术、化疗、肿瘤分期、高血压、血栓史、手术时间、输血、PICC置管、高血脂、糖尿病、D-二聚体,其中有统计学意义的危险因素为BMI(OR=2.65,95%CI:1.61～4.36,P<0.05)、手术(OR=2.33,95%CI:1.62～3.36,P<0.05)、化疗(OR=2.08,95%CI:1.50～2.90,P<0.05)、肿瘤分期(OR=2.42,95%CI:1.54～3.8,P<0.05)、高血压(OR=3.10,95%CI:2.13～4.50,P<0.05)、输血(OR=7.19,95%CI:2.55～20.30,P<0.05)、PICC置管(OR=2.07,95%CI:1.38～3.12,P<0.05)、糖尿病(OR=3.66,95%CI:1.78～7.53,P<0.05)、手术时间≥3 h(OR=1.1,95%CI:1.01～1.20,P<0.05)。【结论】 BMI、手术、化疗、肿瘤分期、高血压、输血、PICC置管、糖尿病、手术时间≥3 h是妇科恶性肿瘤围术期并发DVT的危险因素,可能控制好上述因素可有效降低DVT的发生率。

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	胡正中
	周毅峰
	彭瑨
	秦月兰

关键词 ：生殖器肿瘤,女(雌)性, 妇科外科手术/副作用, 腹腔镜检查, 静脉血栓形成/病因学, 危险因素

Abstract：【Objective】 To investigate the risk factors of perioperative deep venous thrombosis (DVT) in patients with gynecological malignancies. 【Methods】 In this study, we selected the literatures of gynecological malignant tumor complicated with DVT published from January 2010 to December 2019 for META-analysis to explore the risk factors of gynecological tumor patients complicated with DVT during perioperative period.【Results】 A total of 12 articles were included, with 13 risk factors, including age, body mass index (BMI), operation, chemotherapy, tumor stage, hypertension, history of thrombosis, operation time, blood transfusion, PICC catheterization, hyperlipidemia, diabetes, D-dimer. The statistically significant risk factors were BMI (OR=2.65,95%CI:1.61~4.36, P=0.0001), surgery (OR=2.33, 95%CI:1.62~3.36, P<0.0001), chemotherapy (OR=2.08, 95%CI:1.50~2.90, P<0.0001), tumor stage (OR=2.42, 95%CI:1.54~3.8, P<0.0001), hypertension (OR=3.10,95%CI:2.13~4.50,P<0.0001), blood transfusion (OR=7.19, 95%CI: 2.55~20.30, P=0.0002), PICC catheterization (OR=2.07, 95%CI: 1.38~3.12, P=0.0005), diabetes (OR=3.66 , 95%CI:1.78~7.53,P=0.0004), operation time ≥3 h(OR=1.1, 95%CI: 1.01~1.20, P=0.03). 【Conclusion】 BMI, operation, chemotherapy, tumor stage, hypertension, blood transfusion, PICC catheterization, diabetes, operation time ≥3 h are the risk factors of DVT in the perioperative period of gynecological malignant tumor. It is possible that controlling the above factors can effectively reduce the incidence of DVT.

Key words： Genital Neoplasms, Female Gynecologic Surgical Procedures/AE Laparoscopy Venous Thrombosis/ET Risk Factors

收稿日期: 2020-09-04

中图分类号:

R737.3

基金资助:湖南省卫生健康委员会指导项目(编号:20200632)

通讯作者: **E-mail:912542420@qq.com

引用本文:

胡正中, 周毅峰, 彭瑨, 秦月兰. 妇科恶性肿瘤患者围术期并发深静脉血栓的危险因素分析[J]. 医学临床研究, 2021, 38(2): 192-194.
HU Zheng-zhong, ZHOU Yi-feng, PENG Jin, et al. Risk Factors of Deep Venous Thrombosis in Patients with Gynecological Malignancies during Perioperative Period. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 192-194.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.02.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I2/192

[1] 娄英华,沈怡.Caprini血栓风险评估模型预测妇科恶性肿瘤手术患者DVT风险的有效性研究[J].东南大学学报(医学版), 2017, 36(3): 333-337.
[2] 徐姝娟. 深静脉血栓风险评估与预防护理研究进展[J].护理学杂志, 2017,32(7): 110-112.
[3] 黄静.妇科恶性肿瘤并发深静脉血栓形成的危险因素及预后影响因素分析[J].中华妇产科杂志, 2015, 50(10): 762-769.
[4] Verso M, Agnelli G. Prophylaxis against venous thromboembolism in patients with cancer[J].N Engl J Med,2014, 371(13):1262-1264.
[5] 江莉霞.妇科恶性肿瘤术后下肢深静脉血栓的护理研究进展[J].实用妇科内分泌杂志(电子版),2018,5(23):13-14.
[6] Sander G. Quantitative methods in the review of epidemiologic literature[J].Epidemiol Rev,1987, 9(1):12-14.
[7] 严娜, 妇科恶性肿瘤并发深静脉血栓形成危险因素的临床分析[J].福州:福建医科大学,2013.
[8] 王红梅. 妇科恶性肿瘤静脉血栓栓塞发生危险因素分析[D].乌鲁木齐:新疆医科大学,2016.
[9] 吕圣兰.妇科恶性肿瘤术后静脉血栓栓塞的危险因素分析[D].蚌埠:蚌埠医学院,2015.
[10] 熊爱莉. 妇科恶性肿瘤术后静脉血栓形成的风险因素分析[D].南宁:广西医科大学,2018.
[11] 张文通, 卵巢癌患者围手术期静脉血栓栓塞发生危险因素及治疗分析[D].济南:山东大学,2017.
[12] 杜靖然.子宫内膜癌患者围手术期发生下肢深静脉血栓的影响因素[J].国际妇产科学杂志,2019,46(2):150-153.
[13] Kahr HS, Christiansen OB, Høgdall C ,et al. Endometrial cancer does not increase the 30-day risk of venous thromboembolism following hysterectomy compared to benign disease. A danish national cohort study[J].Gynecol Oncol,2019, 155(1): 112-118.
[14] Li Q, Xue YL, Peng Y, et al. Analysis of risk factors for deep venous thrombosis in patients with gynecological malignant tumor: A clinical study[J].Pak J Med Sci,2019, 35(1): 195-199.
[15] Suzuki N,Yoshioka N, Ohara T, et al. Risk factors for perioperative venous thromboembolism: A retrospective study in Japanese women with gynecologic diseases[J].Thromb J,2010, 8(1): 17.[16] Yang T, Tian SJ, Wang YH, et al.Evaluation of risk factors for venous thromboembolism in patients who underwent gynecological surgery and validation of a fast-rating assessment table[J].Med Sci Monit,2019, 25: 8814-8819.
[17] 刘晓静,张一红,李霞,等, 子宫内膜癌术后下肢深静脉血栓形成因素分析[J].护理实践与研究, 2019, 16(23): 106-108.
[18] 蔡琼, 赵淑萍.妇科恶性肿瘤患者术后静脉血栓栓塞疾病(VTE)发生的危险因素及其预防措施[J].中国继续医学教育,2016,8(30):74-75.
[19] 李逃明.妇科恶性肿瘤住院患者并发静脉血栓栓塞的影响因素研究[J].中国医学工程,2019,27(2):30-35.
[20] Agnelli G, Caprini JA. The prophylaxis of venous thrombosis in patients with cancer undergoing major abdominal surgery: emerging options[J].J Surg Oncol,2007, 96(3): 265-272.
[21] 王桂云, 李曼,王海波. 妇科手术后并发静脉血栓临床特征及相关因素分析[J].创伤与急危重病医学, 2019. 7(1): 49-51.
[22] 中国临床肿瘤学会肿瘤与血栓专家共识委员会.中国肿瘤相关静脉血栓栓塞症预防与治疗专家指南(2015版) [J].中国实用内科杂志, 2015, 35(11): 907-920.