Effect of Intravitreal Injection of Conbercept Combined with Retinal Laser Photocoagulation on Long-term Vision and Prognosis in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion
ZHAO Chun-yan, ZHANG Hai-feng, ZHANG Xue-qin, et al
Department of Ophthalmology, Beijing Huairou Hospital Affiliated to the University of Chinese Academy of Sciences, Beijing, 101400, China
Abstract：【Objective】To investigate the effect of intravitreal injection of Conbercept combined with retinal laser photocoagulation on the long-term vision and prognosis of patients with macular edema secondary to branch retinal vein occlusion (BRVO).【Methods】Retrospective analysis of 45 cases (45 eyes) of macular edema secondary to ischemia-type BRVO treated in our hospital from October 2016 to June 2017 was performed, all patients were treated with Conbercept vitreous injection combined with retinal laser photocoagulation; and patients' macular center retinal thickness (CMT), best corrected visual acuity (BCVA) changes were compared1 week,1 month,3 months,6 months,9 months and 12 months pre-treatment and post-treatment , and patient complications and adverse reactions were recorded .【Results】BCVA was 0.44±0.07, 0.45±0.05, 0.52±0.07, 0.54±0.06, 0.62±0.05, 0.90±0.10 at 1 week,3 months,6 months,9 months and 12 months after treatment, respectively, which was significantly higher than 0.39±0.07 before treatment. CMT was (295.14±63.51) mm,(275.39±60.14) mm,(249.63±61.50) mm,(238.75±62.55) mm,(232.64±64.71) mm,(210.08±60.09) mm, respectively, significantly lower than (679.24±62.31) mm before treatment (P<0.05). There was no significant difference in CMT at different time points after treatment (P>0.05). There were no ocular complications such as iatrogenic cataract, high intraocular pressure, retinal tear, vitreous hemorrhage and endophthalmitis.【Conclusion】Conbercept combined with retinal laser photocoagulation can significantly improve BCVA and reduce CMT in patients with macular edema secondary to BRVO, and it has high safety, which is worthy of clinical application.
2020, Vol. 37 
