乙型肝炎患者乙肝五项指标、病毒载量与肝纤维化指标的相关性分析

doi:10.3969/j.issn.1671-7171.2026.08.018

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Abstract 【Objective】 To investigate the correlation of liver fibrosis markers with hepatitis B serological markers (HBV five markers) and HBV-DNA viral load in patients with hepatitis B, and to evaluate their clinical significance. 【Methods】 A total of 137 patients with hepatitis B admitted between April 2024 and April 2025 were enrolled, including 113 patients with chronic hepatitis B (44 mild, 48 moderate, and 21 severe cases) and 24 patients with liver cirrhosis. HBV-DNA viral load and liver fibrosis markers, including procollagen type Ⅲ peptide (PCⅢ), type Ⅳ collagen (CⅣ), laminin (LN), and hyaluronic acid (HA), were compared among different patient groups. The levels of liver fibrosis markers were further analyzed according to HBV-DNA viral load. Spearman correlation analysis was performed to assess the correlations of HBV-DNA viral load, and liver fibrosis markers. 【Results】 The HBV-DNA viral load and the levels of PCⅢ, CⅣ, LN, and HA in patients with chronic hepatitis B were significantly lower than those in patients with liver cirrhosis (P<0.05). The levels of PCⅢ, CⅣ, LN, and HA were significantly correlated with HBV-DNA viral load in patients with hepatitis B (P<0.05). Patients in the HBeAg-positive chronic infection (high infectivity, named "Da Sanyang") group had significantly higher levels of PCⅢ, CⅣ, LN, and HA than the other hepatitis B groups (P<0.05). Correlation analysis showed that HBV-DNA viral load were positively correlated with liver fibrosis markers (P<0.05). 【Conclusion】 Hepatitis B serological markers and HBV-DNA viral load are closely associated with the degree of liver fibrosis in patients with hepatitis B. Active viral replication is strongly associated with the progression of liver fibrosis, particularly in patients with Da Sanyang.

Key words： Hepatitis B Hepatitis B Surface Antigens Hepatitis B Surface Antibody Hepatitis B e Antigens Hepatitis B e Antibody Hepatitis B Core Antibody Hepatic Fibrosis

Received: 29 July 2025

PACS:

R512.62

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	CHEN Yaohua
	YUAN Linchao
	LI Lin

Cite this article:

CHEN Yaohua,YUAN Linchao,LI Lin. Correlation Analysis of Hepatitis B Serological Markers, Viral Load, and Liver Fibrosis Markers in Patients with Hepatitis B[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1298-1301.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1298

[1] 何伟,田水林,施卫兵. 不同年龄段慢性乙型肝炎患者乙肝相关指标与肝纤维化的相关性研究[J].中国医刊,2023,58(12):1307-1312.
[2] 王慧,郝泉水,肖华,等. 乙型肝炎患者血清lncRNA XIST表达与HBV-DNA载量、肝纤维化的关系[J].中国现代医学杂志,2025,35(2):78-82.
[3] 陈春燕,樊子勉. 慢性乙型肝炎者外周血SAA/CRP、NLR水平与HBV-DNA载量、病情程度的相关性分析[J].昆明医科大学学报,2024,45(5):144-150.
[4] 徐锋,程德勇,蒋贻乾,等. 慢性乙型肝炎患者HBV-DNA载量与血清肝纤维化指标的关系[J].浙江临床医学,2021,23(6):888-889.
[5] 中华预防医学会,中国疾病预防控制中心免疫规划中心. 中国成人乙型肝炎免疫预防技术指南[J].中华流行病学杂志,2011,32(12):1199-1203.
[6] Coskun Y, Yuksel I. Serum rheumatoid factor is correlated with liver fibrosis in patients with chronic hepatitis B[J].Wien Klin Wochenschr,2021,133(9/10):432-440.
[7] 杨丽娟,郝小康,周军. 慢性乙型肝炎患者Toll样受体2与乙型肝炎病毒DNA表达水平相关性研究[J].陕西医学杂志,2021,50(6):697-700.
[8] 李娟,董先芳,李玲,等. 慢性乙型肝炎患者HBV-DNA载量与肝功能、肝纤维化程度及T淋巴细胞亚群的关系[J].中华医院感染学杂志,2025,35(4):490-494.
[9] 方茜,江兆涛,郭杰,等. 慢性乙型肝炎患者高敏HBV-DNA定量与HBeAg、HBeAb水平相关性研究[J].标记免疫分析与临床,2021,28(11):1824-1827.
[10] 廖洪柳,徐海锋,徐维蔓. 乙型肝炎肝硬化患者HBV-DNA载量与α-SMA、AFP及肝纤维化的关系[J].中南医学科学杂志,2023,51(6):966-969.
[11] 罗艳. Pre S1、HBV-DNA及乙肝五项指标对乙型肝炎肝脏纤维化诊断的临床价值[J].标记免疫分析与临床,2020,27(1):53-57.
[12] 郭强,赵科孝. HBeAg阴性慢性乙肝合并肝硬化患者血清HBV-DNA水平与肝功能的相关性[J].海南医学,2019,30(8):973-976.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(6): 998-1000.