肠内营养联合肠外营养支持对胃癌根治术患者免疫功能及营养指标的影响

doi:10.3969/j.issn.1671-7171.2026.08.011

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Abstract 【Objective】 To investigate the effects of enteral nutrition (EN) combined with parenteral nutrition (PN) support on immune function and nutritional indicators in patients undergoing radical gastrectomy for gastric cancer. 【Methods】 A total of 80 patients who underwent radical gastrectomy for gastric cancer in Shanghai Pudong New District Punan Hospital from January 2023 to August 2025 were selected and divided into observation group and control group by random number table method, with 40 cases in each group. All patients received radical gastrectomy for gastric cancer. After surgery, the control group was given PN support, while the observation group received EN combined with PN support. Post-operative gastrointestinal function recovery time, defecation time, length of hospital stay and postoperative complications were compared between the two groups. The levels of albumin, prealbumin, hemoglobin, fasting blood glucose, insulin, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) were compared before and after operation. 【Results】 The gastrointestinal function recovery time, defecation time and length of hospital stay in the observation group were significantly shorter than those in the control group (all P<0.05). On postoperative day 7, there were no statistically significant differences in albumin, prealbumin, hemoglobin, fasting blood glucose and insulin in the observation group compared with preoperative levels (all P>0.05). In the control group, albumin, prealbumin and hemoglobin were significantly lower than preoperative values (all P<0.05), while fasting blood glucose and insulin were significantly higher than preoperative values (all P<0.05). The observation group had significantly higher albumin, prealbumin and hemoglobin (all P<0.05), and significantly lower fasting blood glucose and insulin (all P<0.05) compared with the control group. On postoperative day 7, IgA, IgG and IgM levels in both groups were significantly higher than preoperative levels, and those in the observation group were higher than in the control group (all P<0.05). The total incidence of postoperative complications was 22.50% (9/40) in the observation group and 27.50% (11/40) in the control group, with no statistically significant difference (χ²=0.267, P>0.05). 【Conclusion】 EN combined with PN support can improve postoperative immune function and nutritional status in patients with gastric cancer after radical gastrectomy, without increasing the incidence of postoperative complications.

Key words： Stomach Neoplasms Gastrectomy Enteral Nutrition Immune Function Immunoglobulin

Received: 07 January 2026

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R735.2

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	Articles by authors
	WU Wenxue
	QI Yan
	TAO Guoqiang
	WANG Wei
	WANG Yue

Cite this article:

WU Wenxue,QI Yan,TAO Guoqiang, et al. Effects of Enteral Nutrition Combined with Parenteral Nutrition Support on Immune Function and Nutritional Indicators in Patients Undergoing Radical Gastrectomy for Gastric Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1272-1275.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1272

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