血清前白蛋白、淀粉样蛋白A、可溶性髓样细胞触发受体-1对重症急性胰腺炎患者预后的预测效能

doi:10.3969/j.issn.1671-7171.2026.08.010

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Abstract 【Objective】 To investigate the predictive efficacy of serum prealbumin (PA), serum amyloid A (SAA) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for the prognosis of patients with severe acute pancreatitis (SAP). 【Methods】 A total of 121 patients with SAP admitted to our hospital from January 2023 to December 2025 were enrolled. Serum levels of PA, SAA and sTREM-1 were detected after admission. Prognosis was evaluated based on 28-day mortality after admission: 32 deceased patients classified as poor prognosis (the death group) and 89 surviving patients classified as good prognosis (the survival group). Clinical data were compared between the two groups, and prognostic influencing factors were analyzed. Receiver operating characteristic (ROC) curve was adopted to analyze the predictive value of related indicators for patient prognosis. 【Results】 The serum PA level in the poor prognosis group was significantly lower than that in the good prognosis group, while the levels of SAA and sTREM-1 in the poor prognosis group were markedly higher than those in the good prognosis group (P<0.05). The APACHE Ⅱ score and the proportion of complicated with multiple organ failure in the poor prognosis group were higher, whereas the proportion of mechanical ventilation was lower compared to the good prognosis group (P<0.05). Multivariate stepwise Logistic regression analysis revealed that PA was an independent protective factor for prognosis, while SAA, sTREM-1, APACHE Ⅱ score and multiple organ failure were independent risk factors (P<0.05). ROC curve analysis demonstrated that the combined detection of PA, SAA and sTREM-1 yielded a sensitivity of 90.60%, specificity of 91.00% and area under the curve of 0.934 for predicting patient prognosis, which were superior to the predictive performance of each single indicator (P<0.05). 【Conclusion】 Serum PA is an independent protective factor for the prognosis of SAP patients, and SAA and sTREM-1 are independent risk factors. Combined detection of the three biomarkers can effectively predict the prognostic outcomes of SAP patients.

Key words： Severe Acute Pancreatitis Prealbumin Amyloid A Protein Triggering Receptor Expressed on Myeloid Cells-1

Received: 02 February 2026

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R576.1

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	Articles by authors
	ZHANG Wenyu
	CAI Lingle
	ZHANG Chen
	ZHAO Guanlei

Cite this article:

ZHANG Wenyu,CAI Lingle,ZHANG Chen, et al. Predictive Value of Serum Prealbumin, Serum Amyloid A and Soluble Triggering Receptor Expressed on Myeloid Cells-1 for Prognosis in Patients with Severe Acute Pancreatitis[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1268-1271.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1268

[1] Iannuzzi J P, King J A, Leong J H, et al. Global incidence of acute pancreatitis is increasing over time: a systematic review and meta-analysis[J].Gastroenterology,2022,162(1):122-134.
[2] 周泽伟,孙娟,向进平. 血清血管紧张素转化酶2、前白蛋白及血小板活化因子水平能够预测重症急性胰腺炎预后[J].内科急危重症杂志,2023,29(1):49-50.
[3] 谷阁,王润之,张梦辉,等. 血清淀粉样蛋白A联合APACHEⅡ评分对急性胰腺炎预后的预测价值[J].中国急救复苏与灾害医学杂志,2022,17(12):1626-1629.
[4] 蓝远强,吴发胜. 动态监测血清TREM-1和LPS水平对重症胰腺炎早期诊断价值[J].中国急救复苏与灾害医学杂志,2020,15(5):581-583.
[5] 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021)[J].中华消化外科杂志,2021,20(7):730-739.
[6] Varghese Y E, Kalaiselvan M S, Renuka M K,et al. Comparison of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) and acute physiology and chronic health evaluation Ⅳ (APACHE Ⅳ) severity of illness scoring systems, in a multidisciplinary ICU[J].J Anaesthesiol Clin Pharmacol,2017, 33(2):248-253.
[7] 高亚洲,徐之超,殷国志. CT评分联合CRP检测评估重症急性胰腺炎的预后价值分析[J].中国CT和MRI杂志,2022,20(1):122-124.
[8] 张小双,周登川. POP评分联合D-二聚体及前白蛋白对急性胰腺炎严重程度评估价值的研究[J].肝胆外科杂志,2023,31(3):188-192.
[9] Yang X Y, LI R S, XU L, et al. Serum amyloid A3 is required for caerulein-induced acute pancreatitis through induction of RIP3-dependent necroptosis[J].Immunol Cell Biol,2021,99(1):34-48.
[10] 刘娜,邹爱民,韩双,等. 血清SAA、CRP、PCT、IL-6水平与急性胰腺炎患者病情严重程度及预后的相关性分析[J].检验医学与临床,2023,20(3):379-382.
[11] 方妍彬,蒋绚,黄勍,等. 新型血清学指标预测急性胰腺炎严重程度的研究进展[J].胃肠病学和肝病学杂志,2023,32(6):710-713.
[12] 甄品,张昆鹏,左长增,等. 重症急性胰腺炎继发肺部感染患者血清炎症细胞因子水平的变化及临床价值[J].中华医院感染学杂志,2020,30(8):1240-1243.
[13] 秦燕,唐凤英,王彩霞. 外周血miRNA-146a、miRNA-26a在重症急性胰腺炎预后中的价值探讨[J].中国急救复苏与灾害医学杂志,2023,18(1):82-85.
[14] Garg R, Mohammed A, Singh A, et al. Mortality trends, outcomes, and predictors of portal vein thrombosis in acute pancreatitis patients: a propensity-matched national study[J].Dig Dis Sci,2023,68(6):2674-2682.
[15] 董小荣,张蓓,马鑫,等. 构建重症急性胰腺炎患者30 d预后预测Nomogram图[J].中国急救医学,2023,43(5):344-350.