阿托伐他汀钙联合沙库巴曲缬沙坦钠对稳定性冠心病患者PCI术后血压和心功能的影响

doi:10.3969/j.issn.1671-7171.2026.01.025

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Abstract 【Objective】 To explore the effects of atorvastatin calcium combined with sacubitril valsartan sodium on postoperative blood pressure and cardiac function in patients with stable coronary heart disease undergoing percutaneous coronary intervention(PCI). 【Methods】 A retrospective analysis was conducted on the clinical data of 82 stable coronary heart disease patients admitted to our hospital from October 2021 to October 2024. According to different treatment plans, the patients were divided into an observation group and a control group, with 41 cases in each group. Both groups of patients underwent PCI surgery. The control group received atorvastatin calcium after surgery, while the observation group received a combination of sacubitril and valsartan sodium in addition to the control group. The blood pressure [systolic blood pressure(SBP), diastolic blood pressure(DBP)], blood lipid levels[high-density lipoprotein cholesterol(HDL-C), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), triglycerides(TG)], cardiac function [left ventricular end diastolic diameter(LVEDD), left ventricular end systolic diameter(LVESD), left ventricular ejection fraction(LVEF)], and plaque indicators [carotid intima-media thickness(IMT), plaque thickness, plaque area] were compared between two groups of patients before and after treatment. 【Results】 After treatment, DBP and SBP in both groups of patients were lower than before treatment; And both DBP and SBP in the observation group were lower than those in the control group, with a statistically significant difference(P<0.05). The levels of serum TC, TG, and LDL-C in both groups were lower than before treatment, while HDL-C was higher than before treatment. The observation group had lower levels of serum TC, TG, and LDL-C than the control group, while HDL-C was higher than the control group, with statistical significance(P<0.05). The LVEDD and LVESD of the two groups were lower than before treatment, and the LVEF was higher than before treatment. The LVEDD and LVESD of the observation group were lower than those of the control group, and the LVEF was higher than that of the control group, with statistical significance(P<0.05). The IMT, plaque thickness, and plaque area of the two groups were lower than before treatment, and the values in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). 【Conclusion】 Taking atorvastatin calcium and sacubitril valsartan sodium after PCI can effectively improve patients' cardiac function and blood pressure, reduce blood lipid levels, inhibit plaque accumulation, and have good application effects.

Key words： Coronary Disease Atorvastatin Valsartan Angioplasty Blood Pressure

Received: 06 June 2025

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R541.4

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	WANG Xiumei^a
	ZHUANG Yu^b

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WANG Xiumei^a,ZHUANG Yu^b. Effects of Atorvastatin Combined with Sacubitril/Valsartan Combination on Blood Pressure and Heart Function in Stable Coronary Heart Disease Patients Post-Percutaneous Coronary Intervention[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(1): 88-91.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.01.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I1/88

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