慢性丙型肝炎患者血管内皮功能障碍标志物水平及与脑血管反应性的相关性

doi:10.3969/j.issn.1671-7171.2025.08.025

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Abstract 【Objective】 To investigate the levels of serum biomarkers of endothelial dysfunction-intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and vascular endothelial growth factor A (VEGF-A) in patients with chronic hepatitis C (CHC), and their correlation with cerebrovascular reactivity.【Methods】 A total of 50 CHC patients treated in our hospital were included in the hepatitis group, while 30 healthy blood donors were selected as the control group. Levels of ICAM-1, VCAM-1, VEGF-A, and breath-holding index (BHI) were compared between the two groups. Pearson correlation analysis was used to evaluate the association of ICAM-1, VCAM-1 and VEGF-A levels with cerebrovascular reactivity.【Results】 Levels of ICAM-1 and VCAM-1 were significantly higher in the hepatitis group than in the control group (P<0.05), while VEGF-A and BHI in the hepatitis group were significantly lower than those in the control group (P<0.05). Pearson correlation analysis showed that ICAM-1 and VCAM-1 were significantly negatively correlated with BHI in the hepatitis group (r=-0.584 and -0.670, respectively; both P<0.05), whereas VEGF-A was significantly positively correlated with BHI (r=0.604, P<0.05). In the control group, no significant correlation was observed between BHI and levels of ICAM-1, VCAM-1 andVEGF-A (all P>0.05).【Conclusion】 Patients with CHC have significant endothelial dysfunction showing increased serum ICAM-1 and VCAM-1 levels and decreased VEGF-A level, which are significantly correlated with cerebrovascular reactivity as measured by BHI.

Key words： Hepatitis C, Chronic Endothelium, Vascular Biomarkers

Received: 10 April 2025

PACS:

R512.63

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	LU Qiao
	YANG Han
	LIU Jianying

Cite this article:

LU Qiao,YANG Han,LIU Jianying. Correlation of Serum Biomarker Levels of Endothelial Dysfunction with Cerebrovascular Reactivity in Patients with Chronic Hepatitis C[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1382-1384.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.08.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I8/1382

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